Honegger C G, Krenger W, Langemann H
Department of Research, Cantonal Hospital, Basel, Switzerland.
Neurosci Lett. 1989 Apr 10;98(3):327-32. doi: 10.1016/0304-3940(89)90423-0.
Antioxidants (ascorbic acid, glutathione, cysteine, alpha-tocopherol) and uric acid were measured using two high-pressure liquid chromatographic methods in 3 regions (cervical, thoracic, lumbar) of the spinal cord and in blood of Lewis rats during the attack and recovery of experimental autoimmune encephalomyelitis (EAE). Uric acid, which is thought to be a marker of free radical release, was greatly increased and glutathione correspondingly decreased in lumbar and thoracic regions. Cysteine and ascorbic acid were practically unchanged, whereas alpha-tocopherol was significantly increased during attack and recovery. Results, which could have therapeutic implications, generally support the hypothesis that free radicals are released during EAE.
在实验性自身免疫性脑脊髓炎（EAE）发作和恢复期间，使用两种高压液相色谱法对Lewis大鼠脊髓的3个区域（颈段、胸段、腰段）和血液中的抗氧化剂（抗坏血酸、谷胱甘肽、半胱氨酸、α-生育酚）和尿酸进行了测定。尿酸被认为是自由基释放的标志物，在腰段和胸段区域大幅增加，而谷胱甘肽相应减少。半胱氨酸和抗坏血酸基本未变，而α-生育酚在发作和恢复期间显著增加。这些结果可能具有治疗意义，总体上支持了EAE发作期间会释放自由基这一假说。
