Evaluation of Echo Planar Imaging (EPI) Distortion Correction using Synb0-DisCo and Reversed Phase Encoding Acquisition.

Diffusion weighted imaging is a widely used imaging technique for the assessment of white matter using tractography. Nevertheless, due to practical constraints such as limited acquisition times, differences in scanning methods and physical artifacts, these images must be processed by image correction algorithms in order to produce reliable results. State-of-the art susceptibility correction algorithms such as FSL's TOPUP algorithm typically requires at least two images acquired with no diffusion encoding (b=0) in the regular and reverse phase encoding directions, commonly known as double-blip acquisitions, in order to calculate an undistorted volume. Since not all imaging protocols include a double-blip acquisition, they cannot take advantage of these state-of-the art distortion correction algorithms. A new approach based on a Synthetic b-0 Distortion Correction (Synb0-DisCo) has been tested with favourable results. Synb0-DisCo has proven to reduce variation in diffusion modeling creating a synthetic b-0 image to complement the single phase encoding b0 image. In this study, we aim to assess if there are any significant differences in Synb0-DisCo's efficacy resulting from different b-values. To observe critical metrics in the performance of susceptibility correction algorithms we use a 20 healthy subject database from project larynx to create four image sets containing: raw images, single phase encoding eddy correction, double phase encoding eddy correction and one single phase encoding plus a synthetic Synb0-DisCo image eddy correction. From this four image sets we then obtained the mean squared error (MSE) and mutual information (MI). We observed a diminished mean in the MSE, along a smaller dispersion, in the raw image set (Mean: 0.0306; C.I.[0.0369,0.024]) in comparison to the Synb0 image set (Mean: 0.0130; C.I.[0.0194, 0.0067]) We also observe a shift in the MSE depending on the b-value, where b-0 incurs the least MSE which does not occur in b-1000 and b-2000. This effect is lessened in the Synb0 image set. In absence of double phase encoding b-0 image, Synb0-DisCo proves to be a reliable algorithm to improve susceptibility distortion correction.