Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:7132-7135. doi: 10.1109/EMBC46164.2021.9630469.
New types of miniaturized biomedical devices transform contemporary diagnostic and therapeutic techniques in medicine. This evolution has demonstrated exceptional promise in providing infrastructures for enabling precision health by creating diverse sensing modalities. To this end, this paper presents a prototype for transcutaneous carbon dioxide monitoring to diversify the measurable critical parameters for human health. Transcutaneous carbon dioxide monitoring is a noninvasive, surrogate method of assessing the partial pressure of carbon dioxide in the blood. The partial pressure of carbon dioxide is a vital index that can help understand momentarily changing ventilation trends. Therefore, it needs to be reported continuously to monitor the ventilatory status of critically ill patients. The proposed prototype employs an infrared LED as the excitation source. The infrared emission, which decreases in response to an increasing carbon dioxide concentration, is applied to a thermopile sensor that can detect the infrared intensity variations precisely. We have measured the changes in the partial pressure of carbon dioxide in the range of 0-120 mmHg, which covers humans' typical values, 35-45 mmHg. The prototype occupies an area of 25 cm (50 mm × 50 mm) and consumes 85 mW power.
新型微型化生物医学设备改变了当代医学的诊断和治疗技术。这种发展在通过创建多样化的传感模式为实现精准医疗提供基础设施方面表现出了非凡的前景。为此，本文提出了一种用于经皮二氧化碳监测的原型，以多样化可测量的人体健康关键参数。经皮二氧化碳监测是一种非侵入性、替代方法，用于评估血液中二氧化碳分压。二氧化碳分压是一个重要指标，可以帮助了解瞬息万变的通风趋势。因此，需要连续报告以监测危重病患者的通气状态。所提出的原型采用红外 LED 作为激励源。随着二氧化碳浓度的增加而减少的红外发射被应用于热电堆传感器，该传感器可以精确地检测红外强度变化。我们已经测量了 0-120mmHg 范围内的二氧化碳分压变化，该范围涵盖了人类的典型值 35-45mmHg。该原型占地面积为 25cm（50mm×50mm），功耗为 85mW。
