Rabbani Rozhan, Najafiaghdam Hossein, Ghanbari Mohammad Meraj, Papageorgiou Efthymios P, Zhao Biqi, Roschelle Micah, Stojanovic Vladimir, Muller Rikky, Anwar Mekhail
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:7399-7403. doi: 10.1109/EMBC46164.2021.9631061.
Real-time monitoring of cellular-level changes inside the body provides key information regarding disease progression and therapy assessment for critical care including cancer therapy. Current state-of-the-art oncological imaging methods impose unnecessary latencies to detect small cell foci. Invasive methods such as biopsies, on the other hand, cause disruption if deployed on a repeated basis. Therefore, they are not practical for real-time assessments of the tumor tissue. This work presents a proof-of-concept design for an implantable fluorescence lensless image sensor to address the pervasive challenge of real-time tracking of the immune response in immunotherapy. The 2.4x4.7 mm integrated circuit (IC) prototype consists of a 36 by 40 pixel array, a laser driver and a power management unit harvesting power and transferring 11.5 kbits/frame through a wireless ultrasound link while implanted 2 cm deep inside the body. Compared to prior art, this is the first full-fledged wireless system implementing chip-scale fluorescence microscopy to the best of our knowledge.Clinical relevance- This prototype can be used to personalize immunotherapy for the 50% of cancer patients who do not initially respond to the therapy.
对体内细胞水平变化进行实时监测可为包括癌症治疗在内的重症监护中的疾病进展和治疗评估提供关键信息。当前最先进的肿瘤成像方法在检测小细胞病灶时会产生不必要的延迟。另一方面，活检等侵入性方法如果反复使用会造成干扰。因此，它们对于肿瘤组织的实时评估并不实用。这项工作展示了一种可植入荧光无透镜图像传感器的概念验证设计，以应对免疫治疗中实时跟踪免疫反应这一普遍挑战。这个2.4×4.7毫米的集成电路（IC）原型由一个36×40像素阵列、一个激光驱动器和一个电源管理单元组成，该电源管理单元在植入体内2厘米深处时通过无线超声链路收集能量并传输11.5千比特/帧的数据。据我们所知，与现有技术相比，这是首个全面实现芯片级荧光显微镜检查的无线系统。临床意义——该原型可用于为50%最初对治疗无反应的癌症患者定制免疫治疗。
