Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:7476-7479. doi: 10.1109/EMBC46164.2021.9630671.
Continuous monitoring of drug concentrations in blood plasma can be beneficial to guide individualized drug administration. High interpatient variability in required dosage and a small therapeutic window of certain drugs, such as anesthetic medications, can cause risks and challenges in accurate dosing during administration. In this work, we present a sensing platform concept using a smart hydrogel micro resonator sheet with medical ultrasound readout that is integrated on the top of a catheter. This concept is validated in-vitro using glucose as an easy to access and handle target analyte. In the case of continuous glucose measurement, our novel catheter-mounted sensing platform allows the detection of glucose concentrations in the range of 0 mM to 12 mM. While these experiments use a well-known glucose-sensitive smart hydrogel for proof-of-principle experiments, this new sensing platform is intended to provide the basis for continuous monitoring of various intravenously applied medications. Selectivity to different drugs, e.g., fentanyl, can be accomplished by developing a corresponding smart hydrogel composition.Clinical Relevance- Many intravenous medications, especially anesthetics, show considerable pharmacokinetic inter-subject variability. Continuous monitoring of intravenous analyte concentrations would enable individualizing the administration of these drugs to the specific patient.
连续监测血浆中的药物浓度有助于指导个体化给药。某些药物（如麻醉药物）的所需剂量存在较大的个体间差异，治疗窗较窄，因此在给药过程中准确给药会存在风险和挑战。在这项工作中，我们提出了一种使用智能水凝胶微谐振片的传感平台概念，该微谐振片具有医疗超声读出功能，集成在导管的顶部。该概念通过使用葡萄糖作为易于获取和处理的目标分析物进行了体外验证。在连续葡萄糖测量的情况下，我们的新型导管安装式传感平台可检测 0 mM 至 12 mM 范围内的葡萄糖浓度。虽然这些实验使用了众所周知的葡萄糖敏感智能水凝胶进行原理验证实验，但这个新的传感平台旨在为各种静脉内应用药物的连续监测提供基础。通过开发相应的智能水凝胶组成，可以实现对不同药物（如芬太尼）的选择性检测。
临床相关性- 许多静脉内药物，尤其是麻醉药物，在药代动力学方面存在明显的个体间差异。连续监测静脉内分析物浓度可以实现对这些药物的个体化给药，以适应特定患者的需求。
