School of Packaging Materials and Engineering, Hunan University of Technology, Zhuzhou, China; Hunan Provincial Key Laboratory of Comprehensive Utilization of Agricultural and Animal Husbandry Waste Resources, College of Urban and Environmental Sciences, Hunan University of Technology, Zhuzhou, China.
School of Packaging Materials and Engineering, Hunan University of Technology, Zhuzhou, China; Hunan Provincial Key Laboratory of Comprehensive Utilization of Agricultural and Animal Husbandry Waste Resources, College of Urban and Environmental Sciences, Hunan University of Technology, Zhuzhou, China.
Carbohydr Polym. 2022 Feb 1;277:118871. doi: 10.1016/j.carbpol.2021.118871. Epub 2021 Nov 6.
In order to develop better wound dressings, a novel chitosan hydrogel (Cn-Nm gel) was designed and fabricated by using aldehyde-4-arm polyethylene glycol (4r-PEG-CHO) to crosslink the chitosan dissolved in alkaline solution, amino-4-arm polyethylene glycol (4r-PEG-NH) was chosen as the additive simultaneously. The special dissolution technique and macromolecular crosslinking structure endows the Cn-Nm gels with better performance than that of gels prepared by acid dissolving method with micromolecule crosslinker. First, Cn-Nm gels own strong toughness with 500 kPa tensile strength and 1000% elongation, about 400% swelling ratio and fast water absorption rate. Second, about 300 kPa adhesive strength and strippability between the gels and skin is achieved. More importantly, Cn-Nm gels show nearly 100% antibacterial rate towards Escherichia coli and Staphylococcus aureus. Excellent biocompatibility is also proved by the mouse fibroblasts tests. All of the performance makes this developed chitosan-based gel be the potential candidate as a wound dressing.
为了开发更好的伤口敷料，设计并制备了一种新型壳聚糖水凝胶（Cn-Nm 凝胶），使用醛基-4 臂聚乙二醇（4r-PEG-CHO）交联溶解在碱性溶液中的壳聚糖，同时选择氨基-4 臂聚乙二醇（4r-PEG-NH）作为添加剂。特殊的溶解技术和高分子交联结构赋予 Cn-Nm 凝胶比使用酸溶解方法和小分子交联剂制备的凝胶更好的性能。首先，Cn-Nm 凝胶具有很强的韧性，拉伸强度为 500kPa，伸长率为 1000%，溶胀率约为 400%，吸水率快。其次，凝胶与皮肤之间的黏附强度和可剥离性达到约 300kPa。更重要的是，Cn-Nm 凝胶对大肠杆菌和金黄色葡萄球菌的抑菌率接近 100%。通过小鼠成纤维细胞试验也证明了良好的生物相容性。所有这些性能使这种开发的壳聚糖基凝胶成为潜在的伤口敷料候选材料。
