Department of Hepatology, The First Hospital of Jilin University, Changchun, 130021, China.
Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital of Jilin University, Changchun, 130021, China.
Acta Pharmacol Sin. 2022 May;43(5):1167-1179. doi: 10.1038/s41401-021-00819-w. Epub 2021 Dec 10.
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing globally, being the most widespread form of chronic liver disease in the west. NAFLD includes a variety of disease states, the mildest being non-alcoholic fatty liver that gradually progresses to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Small non-coding single-stranded microRNAs (miRNAs) regulate gene expression at the miRNA or translational level. Numerous miRNAs have been shown to promote NAFLD pathogenesis and progression through increasing lipid accumulation, oxidative stress, mitochondrial damage, and inflammation. The miR-23-27-24 clusters, composed of miR-23a-27a-24-2 and miR-23b-27b-24-1, have been implicated in various biological processes as well as many diseases. Herein, we review the current knowledge on miR-27, miR-24, and miR-23 in NAFLD pathogenesis and discuss their potential significance in NAFLD diagnosis and therapy.
非酒精性脂肪性肝病（NAFLD）的发病率在全球范围内正在不断上升，它是西方最普遍的慢性肝病形式。NAFLD 包括多种疾病状态，从轻到重依次为非酒精性脂肪肝，逐渐进展为非酒精性脂肪性肝炎、纤维化、肝硬化，最终发展为肝细胞癌。小的非编码单链微小 RNA（miRNA）在 miRNA 或翻译水平上调节基因表达。大量 miRNA 已被证明通过增加脂质积累、氧化应激、线粒体损伤和炎症来促进 NAFLD 的发病机制和进展。miR-23-27-24 簇由 miR-23a-27a-24-2 和 miR-23b-27b-24-1 组成，与多种生物过程以及许多疾病有关。在此，我们综述了 miR-27、miR-24 和 miR-23 在 NAFLD 发病机制中的最新研究进展，并讨论了它们在 NAFLD 诊断和治疗中的潜在意义。
