Sleep Research Unit, University of Ottawa, Institute of Mental Health Research at the Royal, Ottawa, ON, Canada.
School of Psychology, University of Ottawa, Ottawa, ON, Canada.
Clin EEG Neurosci. 2023 Sep;54(5):451-460. doi: 10.1177/15500594211063311. Epub 2021 Dec 13.
Suicide is the second leading cause of adolescent deaths and may be linked to difficulties with inhibitory and emotional processing. This study assessed the neural correlates of cognitive inhibition during emotional processing in adolescents hospitalized for a suicidal crisis. Event-related potentials were recorded during an emotional Go/NoGo task in 12 adolescents who attempted suicide and 12 age- and sex-matched healthy controls. Compared to the control group, the suicidal group showed significantly reduced positivity at the time of the P3d (difference waveform reflecting NoGo minus Go trials) in response to happy and neutral, but not sad stimuli. For happy stimuli, this group difference was restricted to the right hemisphere. Further analyses indicated that the suicidal group had a reversed pattern of P3 amplitude in response to inhibition, with lower amplitudes in the NoGo compared to the Go conditions. Suicidal symptoms severity strongly correlated with lower amplitude of the P3d in response to neutral faces. These findings provide more insight into inhibition difficulties in adolescents with acute suicidal risk. Interactions between emotional and inhibition processing should be considered when treating acutely suicidal youths.
自杀是青少年死亡的第二大主要原因，可能与抑制和情绪处理困难有关。本研究评估了因自杀危机住院的青少年在进行情绪处理时认知抑制的神经相关性。在一项情绪 Go/NoGo 任务中记录了 12 名尝试自杀的青少年和 12 名年龄和性别匹配的健康对照组的事件相关电位。与对照组相比，自杀组在对快乐和中性刺激（反映 NoGo 与 Go 试验差异的差值波形）的 P3d 时表现出明显减少的正性。对于快乐刺激，这种组间差异仅限于右半球。进一步的分析表明，自杀组在抑制反应中表现出 P3 振幅的反转模式，与 Go 条件相比，NoGo 条件的振幅较低。自杀症状严重程度与对中性面孔的 P3d 反应幅度较低强烈相关。这些发现为处于急性自杀风险的青少年的抑制困难提供了更多的见解。在治疗急性自杀的青少年时，应考虑情绪和抑制处理之间的相互作用。
