SOCS6 下调：生存分析证实其为胃肠道间质瘤的不利预后因素。
Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis.
机构信息
Center of Digestive Diseases, The Seventh Affiliated Hospital, Sun Yat-sen University, Zhenyuan Road 628, Guangming District, Shenzhen, Guangdong, China.
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Road 58, Yuexiu District, Guangzhou, Guangdong, China.
出版信息
Diagn Pathol. 2021 Dec 12;16(1):113. doi: 10.1186/s13000-021-01172-6.
BACKGROUND
Many studies reporting that down-regulation of SOCS6 plays vital roles in promoting progression of malignant tumors have been published. The present study was performed to evaluate whether SOCS6 was significantly associated with prognosis of GIST patients.
METHODS
Immunohistochemical staining was accomplished to evaluate the expression levels of SOCS6 among GIST patients. The impacts of SOCS6 expression on overall survival (OS) and recurrence-free survival (RFS) of GIST patients were assessed by Cox proportional hazard regression model analysis and Kaplan-Meier curve analysis.
RESULTS
It was demonstrated that the expression level of SOCS6 was significantly associated with tumor size (P=0.001). Then according to Kaplan-Meier curve analysis, low expression of SOCS6 was significantly correlated with worse OS and RFS of GIST patients. Ultimately, it was revealed by Cox proportional regression model analysis that low expression of SOCS6 was an independent predictive factor for OS and RFS.
CONCLUSIONS
Low expression of SOCS6 was an independent prognostic factor for GIST, suggesting its potential as a novel biomarker predicting survival of GIST patients.
背景
许多研究报告表明，SOCS6 的下调在促进恶性肿瘤的进展中起着至关重要的作用。本研究旨在评估 SOCS6 是否与 GIST 患者的预后显著相关。
方法
采用免疫组织化学染色法评估 GIST 患者 SOCS6 的表达水平。通过 Cox 比例风险回归模型分析和 Kaplan-Meier 曲线分析评估 SOCS6 表达对 GIST 患者总生存（OS）和无复发生存（RFS）的影响。
结果
结果表明，SOCS6 的表达水平与肿瘤大小显著相关（P=0.001）。然后，根据 Kaplan-Meier 曲线分析，SOCS6 的低表达与 GIST 患者的 OS 和 RFS 较差显著相关。最终，通过 Cox 比例回归模型分析发现，SOCS6 的低表达是 OS 和 RFS 的独立预测因素。
结论
SOCS6 的低表达是 GIST 的独立预后因素，提示其可能成为预测 GIST 患者生存的新型生物标志物。
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