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Cell Metab. 2021 Nov 2;33(11):2174-2188.e5. doi: 10.1016/j.cmet.2021.09.009. Epub 2021 Sep 16.
2
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study.高雌二醇和低睾酮水平与男性 COVID-19 患者的重症相关，但与女性 COVID-19 患者无关：一项回顾性队列研究。
Emerg Microbes Infect. 2021 Dec;10(1):1807-1818. doi: 10.1080/22221751.2021.1969869.
3
Dissecting lipid metabolism alterations in SARS-CoV-2.解析 SARS-CoV-2 中的脂质代谢改变。
Prog Lipid Res. 2021 Apr;82:101092. doi: 10.1016/j.plipres.2021.101092. Epub 2021 Feb 8.
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Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.糖尿病、肥胖症、新陈代谢与新型冠状病毒感染：开端的结束。
Cell Metab. 2021 Mar 2;33(3):479-498. doi: 10.1016/j.cmet.2021.01.016. Epub 2021 Jan 21.
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How obesity could create problems for a COVID vaccine.肥胖如何给新冠疫苗带来问题。
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Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.SARS-CoV-2 Nsp1 蛋白通过翻译关闭和免疫逃避的结构基础。
Science. 2020 Sep 4;369(6508):1249-1255. doi: 10.1126/science.abc8665. Epub 2020 Jul 17.
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COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.COVID-19 感染改变犬尿氨酸和脂肪酸代谢，与 IL-6 水平和肾脏状况相关。
JCI Insight. 2020 Jul 23;5(14):140327. doi: 10.1172/jci.insight.140327.
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Pathogenesis and transmission of SARS-CoV-2 in golden hamsters.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在金黄仓鼠中的发病机制与传播
Nature. 2020 Jul;583(7818):834-838. doi: 10.1038/s41586-020-2342-5. Epub 2020 May 14.
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Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models.宿主差异决定因素导致 2009 年大流行 H1N1 和人源 H5N1 流感病毒在实验小鼠模型中的发病机制不同。
Am J Pathol. 2011 Jul;179(1):230-9. doi: 10.1016/j.ajpath.2011.03.041. Epub 2011 May 18.
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Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells.源自永生化人骨髓间充质干细胞的胰岛素敏感脂肪细胞中脂质代谢的特征分析
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SARS-CoV-2 在脂肪组织中的复制决定了仓鼠和人类的器官和全身脂质代谢。

Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans.

机构信息

Leibniz Institute for Experimental Virology, Hamburg, Germany.

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Cell Metab. 2022 Jan 4;34(1):1-2. doi: 10.1016/j.cmet.2021.12.002. Epub 2021 Dec 10.

DOI:10.1016/j.cmet.2021.12.002
PMID:34895500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8663969/
Abstract

Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.

摘要

Zickler 等人描述了人脂肪组织尸检样本中的 SARS-CoV-2 RNA。在仓鼠模型中，SARS-CoV-2 在脂肪组织中的传播导致脂质代谢的特定变化，这些变化反映在仓鼠和人血浆的脂质组图谱中。