Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, F-75005 Paris, France.
Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, F-75005 Paris, France.
Drug Discov Today Technol. 2020 Dec;37:117-124. doi: 10.1016/j.ddtec.2019.06.001. Epub 2019 Jun 27.
In this review, we present an overview of some of the medicinally-relevant organometallic drugs that have been used in the past or that are currently in clinical trials as well as an example of compounds that are currently in the initial stage of drug development. Three main classes of organometallic complexes have been chosen for discussion: antimicrobial organoarsenicals, antimalarial and anticancer ferrocene-containing compounds and anticancer catalytic organometallic complexes. The purpose of this review is to provide readers with a focus on the significant progress that has been made for each of these respective fields of medicine.
在这篇综述中，我们介绍了一些过去曾用于医学或目前正在临床试验中的药用金属有机药物，以及一些处于药物开发初始阶段的化合物的例子。选择了三类主要的金属有机配合物进行讨论：抗菌有机胂化合物、抗疟和抗癌含二茂铁化合物以及抗癌催化金属有机配合物。本文的目的是为读者提供一个重点，了解这些医学领域各自取得的重要进展。
