Favaro S, Meneghel G, Rouben G, Piccoli A, Borsatti A
Clin Nephrol. 1986 Aug;26(2):101-5.
Comparative study of peripheral blood lymphocyte surface markers in chronic pyelonephritis (CP) and chronic glomerulonephritis (GN) patients, and in normal controls showed no differences between controls and GN patients. In CP patients, a significant absolute increase in B cells, and an absolute decrease in T cells were observed as well as significantly lower and higher percentages of OKT4 and OKT8 cells, respectively, leading to a decrease in the OKT4/OKT8 ratio. Furthermore, the percentage of large granular cells was significantly higher in CP patients, while no differences in TIa cells emerged. The overall picture shown by the CP patients is compatible to a cell-mediated immune (CMI) response defect.
对慢性肾盂肾炎（CP）患者、慢性肾小球肾炎（GN）患者以及正常对照者外周血淋巴细胞表面标志物的比较研究显示，对照者与GN患者之间无差异。在CP患者中，观察到B细胞绝对数量显著增加，T细胞绝对数量减少，同时OKT4细胞和OKT8细胞的百分比分别显著降低和升高，导致OKT4/OKT8比值下降。此外，CP患者中大颗粒细胞的百分比显著更高，而TIa细胞无差异。CP患者呈现的整体情况符合细胞介导免疫（CMI）反应缺陷。
