Inserm CIC1427, Clinical Investigations Center, hôpital Saint-Louis, université de Paris, AP-HP, 75010 Paris, France; Inserm UMR 944, Saint-Louis Research Institute, 75010 Paris, France.
Inserm CIC1427, Clinical Investigations Center, hôpital Saint-Louis, université de Paris, AP-HP, 75010 Paris, France; Inserm UMR 1131, Saint-Louis Research Institute, 75010 Paris, France.
Therapie. 2022 Mar-Apr;77(2):151-155. doi: 10.1016/j.therap.2021.11.007. Epub 2021 Nov 25.
Target identification and drug discovery roads have been widely improved over the past decades in onco-hematology. In this review, we summarize recent improvements in the use of physio-pathologically relevant models and innovative screening approaches to accelerate efficient drug development. Using acute myeloid leukemia as an example, we also discuss the main encountered pitfalls and propose alternative roads to improve the drug discovery journey in onco-hematology.
在肿瘤血液学领域，过去几十年来，目标识别和药物发现的途径已经得到了广泛的改进。在这篇综述中，我们总结了最近在使用生理病理相关模型和创新筛选方法方面的进展，以加速有效的药物开发。我们还以急性髓细胞白血病为例，讨论了主要遇到的陷阱，并提出了改进肿瘤血液学药物发现途径的替代方法。
