Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.
Food Chem Toxicol. 2022 Jan;159:112762. doi: 10.1016/j.fct.2021.112762. Epub 2021 Dec 9.
Herbal products are being increasingly used all over the world for preventive and therapeutic purposes because of the belief of their safety. They have become an important part of health care system in many countries since they can easily be purchased in the health food stores or online. However, the lack of sufficient study on their efficacy and toxicity, inadequate controls of their availability, reduce their safety. Unlike conventional drugs, herbal products are not regulated for purity and potency. Herbal products contain substances which can induce or inhibit enzymes that take part in drug metabolism. Therefore the concurrent use of drugs with some medicinal plants can cause serious adverse effects and can also decrease the efficacy of the therapy. Particularly, drugs with narrow therapeutic index and plants which can affect drug metabolizing enzymes when used together, may lead to unpredictable adverse reactions. Impurities, contaminants and adulterants found in the herbal products, are the most common malpractises in herbal raw-material trade. In this review the unpredictable adverse effects of herbal products due to their possible interactions with drugs and also due to the adulteration and contamination with prohibited chemicals will be discussed in detail.
由于人们相信其安全性，草药产品在全世界范围内被越来越多地用于预防和治疗目的。由于它们可以在保健食品商店或在线轻松购买，因此已成为许多国家医疗保健系统的重要组成部分。但是，由于对其功效和毒性的研究不足，对其供应的控制不足，降低了它们的安全性。与传统药物不同，草药产品的纯度和效力不受监管。草药产品中含有可诱导或抑制参与药物代谢的酶的物质。因此，药物与某些药用植物同时使用会引起严重的不良反应，并且还会降低治疗效果。特别地，具有狭窄治疗指数的药物和可一起影响药物代谢酶的植物，可能会导致不可预测的不良反应。在草药产品中发现的杂质，污染物和掺杂物是草药原料贸易中最常见的违法行为。在本次综述中，将详细讨论由于草药产品可能与药物相互作用以及由于掺假和受禁用化学物质污染而导致的不可预测的不良反应。
