Yanai K, Ido T, Ishiwata K, Hatazawa J, Takahashi T, Iwata R, Matsuzawa T
Eur J Nucl Med. 1986;12(3):141-6. doi: 10.1007/BF00276707.
The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.
内源性致幻剂N,N-二甲基色胺（DMT）用碳-11进行标记，并对其在大鼠脑中的区域分布进行了研究。[11C]DMT在大脑皮层、尾状壳核和杏仁核中显示出较高的蓄积。对[11C]DMT亚细胞分布的研究表明，只有在向大鼠注射极低剂量时，才会在富含5-羟色胺受体的组分中出现特异性定位。用单胺氧化酶抑制剂帕吉林预处理后，富含受体组分中的放射性比例大大提高。正电子发射断层扫描研究证实了[11C]DMT与犬脑5-羟色胺受体的特异性结合，其中5-甲氧基-N,N-二甲基色胺可使放射性配体从受体上产生约20%的位移。
