Shams N B, Sigel M M, Davis J F, Ferguson J G
Invest Ophthalmol Vis Sci. 1986 Oct;27(10):1543-5.
Synthesis of thromboxane, a product of arachidonic acid formed via the cyclooxygenase pathway, was studied in rabbit corneal epithelial cells (SIRC cell line) under resting conditions and under the influence of interleukin 1 (IL-1). IL-1 potentiated the production of thromboxane 3-10-fold in a dose-dependent manner. This finding assumes added significance in view of the previous observations that the same cells are capable of producing IL-1. Thus, the corneal epithelial cells may be viewed in this context as an autocrine cell producing two biologically active substances which can serve as mediators of inflammation, one of which can augment the production of the other.
通过环氧化酶途径形成的花生四烯酸产物血栓素的合成，在静息条件下以及白细胞介素1（IL-1）影响下的兔角膜上皮细胞（SIRC细胞系）中进行了研究。IL-1以剂量依赖性方式使血栓素的产生增强3至10倍。鉴于先前观察到相同细胞能够产生IL-1，这一发现具有额外的重要意义。因此，在这种情况下，角膜上皮细胞可被视为产生两种具有生物活性物质的自分泌细胞，这两种物质可作为炎症介质，其中一种可增强另一种的产生。
