HCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London NW9 5EQ, UK.
National Institute for Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford, Oxford OX3 9DU, UK.
J Antimicrob Chemother. 2022 Feb 23;77(3):799-802. doi: 10.1093/jac/dkab443.
Antibacterial prescribing for respiratory tract infections (RTIs) accounts for almost half of all prescribing in primary care. Nearly a quarter of antibacterial prescribing in primary care is estimated to be inappropriate, the greatest being for RTIs. The COVID-19 pandemic has changed the provision of healthcare services and impacted the levels of antibacterials prescribed.
To describe the changes in community antibacterial prescribing for RTIs in winter 2020-21 in England.
RTI antibacterial prescribing was measured in prescription items/1000 population for primary care from January 2014 and in DDDs/1000 population/day for the totality of RTI prescribing [combined with Accident & Emergency (A&E) in secondary care], from January 2016 to February 2021. Trends were assessed using negative binomial regression and seasonally adjusted interrupted time-series analysis.
Antibacterials prescribed for RTIs reduced by a further 12.4% per season compared with pre-COVID (P < 0.001). In winter 2020-21, RTI prescriptions almost halved compared with the previous winter in 2019-20 (P < 0.001). The trend observed for total RTI prescribing (primary care with A&E) was similar to that observed in the community alone.
During COVID-19, RTI prescribing reduced in the community and the expected rise in winter was not seen in 2020-21. We found no evidence that RTI prescribing shifted from primary care to A&E in secondary care. The most likely explanation is a decrease in RTIs and presentations to primary care associated with national prevention measures for COVID-19.
呼吸道感染(RTI)的抗菌药物处方占初级保健中所有处方的近一半。估计初级保健中近四分之一的抗菌药物处方是不适当的,其中最大的是用于 RTI。COVID-19 大流行改变了医疗保健服务的提供方式,并影响了抗菌药物的处方量。
描述英格兰 2020-21 年冬季社区 RTIs 抗菌药物处方的变化。
从 2014 年 1 月开始,以初级保健每千人处方项目数测量 RTI 抗菌药物处方,从 2016 年 1 月到 2021 年 2 月,以每千人每日 DDD 数测量 RTI 总处方(与二级保健中的急症室相结合)。使用负二项回归和季节性调整的中断时间序列分析评估趋势。
与 COVID 前相比,RTI 抗菌药物处方每季节进一步减少 12.4%(P<0.001)。2020-21 年冬季,与 2019-20 年同期相比,RTI 处方几乎减半(P<0.001)。初级保健与急症室相结合的总 RTI 处方观察到的趋势与社区内观察到的趋势相似。
在 COVID-19 期间,社区内 RTI 处方减少,2020-21 年冬季没有出现预期的上升。我们没有发现 RTI 处方从初级保健转移到二级保健急症室的证据。最可能的解释是与 COVID-19 国家预防措施相关的 RTIs 和初级保健就诊减少。