Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Epidemiology, IQVIA, Frankfurt, Germany.
J Cancer Res Clin Oncol. 2022 Nov;148(11):3039-3046. doi: 10.1007/s00432-021-03867-1. Epub 2021 Dec 12.
There is a growing body of evidence suggesting a decisive involvement of the human lipid metabolism in cancer development. However, clinical data on the association between blood triglyceride or cholesterol levels including the cholesterol transporters high-density and low-density lipoproteins (LDL, HDL) and cancer incidence have remained inconclusive. Here, we investigated the association between blood triglyceride as well as total, LDL and HDL cholesterol levels and cancer among outpatients from Germany.
61,936 patients with available blood lipid values were identified from the IQVIA Disease Analyzer database and followed up between 2005 and 2019. Multivariable logistic regression models were used to study the association between lipid values and cancer.
The probability of cancer was significantly lower among patients with elevated total cholesterol concentrations and higher in patients with decreased HDL serum levels. In contrast, serum concentrations of LDL and triglycerides had no impact on cancer risk. In cancer site-stratified analyses, we observed a trend towards higher rates of cancers from digestive organs, breast, skin cancer, urinary tract and cancers from lymphoid and hematopoietic tissue in patients with HDL values < 35 mg/dl, while a negative association between total cholesterol > 250 mg/dl and respiratory organ as well as urinary tract cancers was observed.
Our data strongly support the hypothesis that serum-specific lipid profiles are positively associated with cancer.
越来越多的证据表明，人类的脂质代谢在癌症的发展中起着决定性的作用。然而，关于血液甘油三酯或胆固醇水平（包括胆固醇转运蛋白高密度脂蛋白和低密度脂蛋白（LDL、HDL）与癌症发病率之间的关联的临床数据仍未有定论。在这里，我们研究了德国门诊患者的血液甘油三酯以及总胆固醇、LDL 和 HDL 胆固醇水平与癌症之间的关系。
从 IQVIA Disease Analyzer 数据库中确定了 61936 名有可用血脂值的患者，并在 2005 年至 2019 年期间进行了随访。使用多变量逻辑回归模型研究了血脂值与癌症之间的关系。
总胆固醇浓度升高的患者患癌症的概率显著降低，而 HDL 血清水平降低的患者患癌症的概率更高。相比之下，LDL 和甘油三酯的血清浓度对癌症风险没有影响。在癌症部位分层分析中，我们观察到 HDL 值<35mg/dl 的患者中来自消化器官、乳房、皮肤癌、泌尿系统和淋巴造血组织的癌症发生率较高，而总胆固醇>250mg/dl 与呼吸道和泌尿系统癌症之间存在负相关。
我们的数据强烈支持这样的假设，即血清特定的脂质谱与癌症呈正相关。
