Department of Epidemiology, College of Public Health, Harbin Medical University, 157 Baojian Street, Harbin, Heilongjiang Province, 150081, People's Republic of China.
Department of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, 157 Baojian Street, Harbin, Heilongjiang, 150081, People's Republic of China.
BMC Cancer. 2020 Mar 12;20(1):200. doi: 10.1186/s12885-020-6679-9.
Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) differed between cases and non-cases of OT.
Electronic repositories; PUBMED, EMBASE and Cochrane library were explored through December 2019 to retrieve published articles for inclusion in the meta-analysis after quality assessment. Heterogeneity was assessed using I statistics, the effect of individual studies on the overall effect size was tested using sensitivity analysis and funnel plot was used to evaluate publication bias.
Twelve studies, involving 1767 OT cases and 229,167 non-cases of OT were included in this meta-analysis and I statistics ranged between 97 and 99%. Mean circulating TC (- 16.60 [- 32.43, - 0.77]mg/dL; P = 0.04) and HDL (- 0.25[- 0.43, - 0.08]mmol/L; P = 0.005) were significantly lower among OT cases compared to non-OT cases.
Decreased TC and HDL profiles were observed among subjects with OT in this collection of reports. The implications of TC and HDL in tumour manifestations and growth need to be validated in a large multi-ethnic longitudinal cohort adjusting for relevant confounders.
现有几份关于血脂谱与卵巢肿瘤（OT）之间关联的报告数据得出了不同的结论。我们的目的是研究循环血脂谱：总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）是否在 OT 病例与非病例之间存在差异。
通过电子数据库（PUBMED、EMBASE 和 Cochrane 图书馆）检索截至 2019 年 12 月发表的文章，进行质量评估后纳入荟萃分析。使用 I ²统计量评估异质性，使用敏感性分析测试个别研究对总效应大小的影响，并使用漏斗图评估发表偏倚。
这项荟萃分析共纳入了 12 项研究，涉及 1767 例 OT 病例和 229167 例非 OT 病例，I ²统计量范围在 97%至 99%之间。与非 OT 病例相比，OT 病例的循环 TC（-16.60[-32.43，-0.77]mg/dL；P=0.04）和 HDL（-0.25[-0.43，-0.08]mmol/L；P=0.005）水平显著降低。
在这组报告中，OT 患者的 TC 和 HDL 水平较低。TC 和 HDL 在肿瘤表现和生长中的作用需要在一个大型多民族纵向队列中进行验证，并调整相关混杂因素。
