From the Department of Pediatric Anesthesia, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Northwestern University Feinberg School of Medicine, Chicago, Illinois.
A A Pract. 2022 Jan 5;16(1):e01551. doi: 10.1213/XAA.0000000000001551.
Bleomycin is a cytotoxic antibiotic that has a sclerosing effect on vascular endothelium. Small doses can be injected locally to reduce the size of various vascular malformations. Recognition that targeted intralesional injection carries the potential to cause hyperpigmentation, specifically in areas of skin trauma, and has led our department to implement a bleomycin skin-protective protocol. On review of cases performed following protocol implementation, no patients developed hyperpigmentation attributable to iatrogenic skin trauma. We present our bleomycin skin protection protocol to guide peer institutions in the initiation of similar quality improvement initiatives.
平阳霉素是一种细胞毒性抗生素，对血管内皮具有硬化作用。小剂量可局部注射，以缩小各种血管畸形的大小。认识到靶向瘤内注射有可能导致色素沉着，特别是在皮肤创伤区域，这促使我们科室实施了平阳霉素皮肤保护方案。在实施方案后对进行的病例进行回顾，没有患者因医源性皮肤创伤而出现色素沉着。我们提出平阳霉素皮肤保护方案，以指导同行机构开展类似的质量改进举措。
