School of System Biology, College of Science, George Mason University, Fairfax, Virginia, USA.
Research Center for Medical Genetics RAMS, Moscow, Russia.
Clin Transl Med. 2021 Dec;11(12):e668. doi: 10.1002/ctm2.668.
The level of postvaccine protection depends on two factors: antibodies and T-cell responses. While the first one is relatively easily measured, the measuring of the second one is a difficult problem. The recent studies indicate that the first one may be a good proxy for the protection, at least for SARS-CoV-2. The massive data currently gathered by both researcher and citizen scientists may be pivotal in confirming this observation, and the collective body of evidence is growing daily. This leads to an acceptance of IgG antibody levels as an accessible biomarker of individual's protection. With enormous and immediate need for assessing patient condition at the point of care, quantitative antibody analysis remains the most effective and efficient way to assess the protection against the disease. Let us not discount importance of reference points in the turmoil of current pandemics.
抗体和 T 细胞反应。虽然前者相对容易测量，但后者的测量是一个难题。最近的研究表明，前者可能是保护的良好替代指标，至少对于 SARS-CoV-2 是如此。研究人员和公民科学家目前收集的大量数据可能对证实这一观察结果至关重要，而且证据不断增加。这导致 IgG 抗体水平作为个体保护的可及生物标志物被接受。由于在护理点评估患者病情的巨大且即时需求，定量抗体分析仍然是评估针对该疾病的保护的最有效和最有效的方法。让我们在当前大流行的混乱中不要低估参考点的重要性。
