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一种单克隆抗体定义的B系转化抗原的表达可特异性识别艾贝尔森病动物。对艾贝尔森鼠白血病病毒的遗传抗性在gp160(6C3)诱导之前起作用。

Expression of a monoclonal antibody-defined, B-lineage transformation antigen specifically identifies Abelson-diseased animals. Genetically determined resistance to Abelson murine leukemia virus acts before induction of gp160(6C3).

作者信息

Tidmarsh G F, Dailey M O, Weissman I L

出版信息

J Exp Med. 1986 Oct 1;164(4):1356-61. doi: 10.1084/jem.164.4.1356.

DOI:10.1084/jem.164.4.1356
PMID:3489809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188414/
Abstract

Mice genetically susceptible or genetically resistant to the leukemogenic effects of A-MuLV(Mo) were tested for their expression of the B-lineage neoplastic transformation-associated antigen, 6C3Ag. Genetically resistant inbred strains and recombinant inbred lines developed neither cells expressing high levels of 6C3Ag (6C3Aghi) in their hematolymphoid tissues nor Abelson leukemias. Genetically susceptible inbred strains and recombinant inbred lines developed high percentages of 6C3Aghi hematolymphoid cells concomitant with development of Abelson leukemias and lymphomas. Thus the genetically-determined resistance to A-MuLV(Mo) leukemogenesis appears to act at some step(s) after virus infection but before the stage of malignant progression, which is marked by 6C3Ag expression.

摘要

对在基因上对A-MuLV（Mo）致白血病作用敏感或有抗性的小鼠，检测其B系肿瘤转化相关抗原6C3Ag的表达情况。具有基因抗性的近交系和重组近交系在其血液淋巴组织中既未产生表达高水平6C3Ag（6C3Aghi）的细胞，也未发生Abelson白血病。具有基因易感性的近交系和重组近交系在出现Abelson白血病和淋巴瘤的同时，产生了高比例的6C3Aghi血液淋巴细胞。因此，基因决定的对A-MuLV（Mo）白血病发生的抗性似乎在病毒感染后的某些步骤起作用，但在以6C3Ag表达为标志的恶性进展阶段之前。

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Expression of a monoclonal antibody-defined, B-lineage transformation antigen specifically identifies Abelson-diseased animals. Genetically determined resistance to Abelson murine leukemia virus acts before induction of gp160(6C3).一种单克隆抗体定义的B系转化抗原的表达可特异性识别艾贝尔森病动物。对艾贝尔森鼠白血病病毒的遗传抗性在gp160(6C3)诱导之前起作用。
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引用本文的文献

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Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen.正常胸腺皮质上皮细胞在发育过程中调节B细胞系转化相关抗原的表达。
Immunogenetics. 1988;27(3):180-6. doi: 10.1007/BF00346584.
2
Aminopeptidase A activity of the murine B-lymphocyte differentiation antigen BP-1/6C3.小鼠B淋巴细胞分化抗原BP-1/6C3的氨肽酶A活性
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):676-80. doi: 10.1073/pnas.88.2.676.

本文引用的文献

1
Transformation-associated proteins in murine B-cell lymphomas that are distinct from Abelson virus gene products.与阿贝尔森病毒基因产物不同的小鼠B细胞淋巴瘤中的转化相关蛋白。
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4434-8. doi: 10.1073/pnas.81.14.4434.
2
Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus.含有劳氏肉瘤病毒src基因的鼠重组逆转录病毒对造血细胞的转化
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2374-8. doi: 10.1073/pnas.81.8.2374.
3
Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential.艾贝尔逊病毒感染的细胞在体外可能表现出生长受限和致癌潜力较低的情况。
J Virol. 1981 Nov;40(2):577-84. doi: 10.1128/JVI.40.2.577-584.1981.
4
Transformed lymphocytes from Abelson-diseased mice express levels of a B lineage transformation-associated antigen elevated from that found on normal lymphocytes.来自艾贝尔森病小鼠的转化淋巴细胞表达一种与B淋巴细胞系转化相关的抗原，其水平高于正常淋巴细胞上发现的水平。
J Exp Med. 1985 Nov 1;162(5):1421-34. doi: 10.1084/jem.162.5.1421.
5
Conjugation of antibodies with fluorochromes: modifications to the standard methods.抗体与荧光染料的偶联：对标准方法的改进
J Immunol Methods. 1976;13(3-4):215-26. doi: 10.1016/0022-1759(76)90068-5.
6
Abelson virus-induced lymphomagenesis in mice.阿贝尔森病毒诱导的小鼠淋巴瘤发生
J Exp Med. 1978 Sep 1;148(3):714-26. doi: 10.1084/jem.148.3.714.

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