阿贝尔森病毒诱导的小鼠淋巴瘤发生
Abelson virus-induced lymphomagenesis in mice.
作者信息
Risser R, Potter M, Rowe W P
出版信息
J Exp Med. 1978 Sep 1;148(3):714-26. doi: 10.1084/jem.148.3.714.
Abstract
The salient facts which have emerged from our study of Abelson virus (MuLV-A)lymphomagenesis in mice are that lymphoma induction is (a) age dependent, (b) virus dose dependent, and (c) under the control of host genes unrelated to other genes known to control murine leukemia (e.g., Fv-1 on Fv-2). Of 16 strains tested, only BALB/c and some of its derivative strains showed high sensitivity. Studies from CXB recombinant inbred strains and hybrids between them are interpreted to indicate that BALB/c carries dominant sensitivity alleles at two loci, tentatively designated Av-1 and Av-2, which conferon these mice partial susceptibility to MuLV-A lymphoma induction. In addition, H-2 may play a minor role in determining the susceptibility of mice to MuLV-A, its effect being seen only in mice homozygous for resistance at both Av-1 and Av-2. Virologic studies indicate that the resistance of adult B6 mice is not related to restriction on the helper virus replication, but is specific for the defective transforming virus genome.
摘要
我们对小鼠阿贝尔森病毒（MuLV-A）淋巴瘤发生机制的研究中出现的显著事实是，淋巴瘤诱导具有以下特点：（a）依赖年龄，（b）依赖病毒剂量，以及（c）受与已知控制鼠白血病的其他基因（如Fv-1和Fv-2）无关的宿主基因控制。在测试的16个品系中，只有BALB/c及其一些衍生品系表现出高敏感性。对CXB重组近交系及其之间杂种的研究表明，BALB/c在两个位点携带显性敏感等位基因，暂定为Av-1和Av-2，这使这些小鼠对MuLV-A淋巴瘤诱导具有部分易感性。此外，H-2在决定小鼠对MuLV-A的易感性方面可能起次要作用，其作用仅在Av-1和Av-2均为纯合抗性的小鼠中可见。病毒学研究表明，成年B6小鼠的抗性与辅助病毒复制的限制无关，而是对缺陷转化病毒基因组具有特异性。
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