J Drugs Dermatol. 2021 Dec 1;20(12):1350-1351. doi: 10.36849/jdd.6176.
Perniosis (also known as pernio or chilblains), is a condition characterized by the development of pruritic, painful erythrocyanotic skin lesions induced by exposure to cold temperatures.2 When perniosis occurs in conjunction with clinical or laboratory features of systemic lupus erythematosus, the condition is further classified as chilblain lupus erythematosus (CHLE). CHLE is a rare condition with limited treatment options especially in refractory cases.3 Here we discuss the utility of therapeutic botulinum toxin injections in the treatment of severe, ulcerative CHLE. J Drugs Dermatol. 2021;20(12):1350-1351. doi:10.36849/JDD.6176.
冻疮（也称为冻疮或寒冷性多形红斑）是一种由暴露于寒冷温度引起的瘙痒、疼痛的红细胞性皮肤损伤的疾病。2当冻疮伴有红斑狼疮的临床或实验室特征时，这种情况进一步分类为寒冷性多形红斑狼疮（CHLE）。CHLE 是一种罕见的疾病，治疗选择有限，尤其是在难治性病例中。3 在这里，我们讨论了治疗性肉毒毒素注射在治疗严重、溃疡性 CHLE 中的效用。J 皮肤病药物杂志。2021;20(12):1350-1351. doi:10.36849/JDD.6176.
