Villarreal-Otalvaro Carolina, Coburn Jeannine M
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States.
ACS Biomater Sci Eng. 2023 Jul 10;9(7):3832-3842. doi: 10.1021/acsbiomaterials.1c00685. Epub 2021 Dec 13.
Despite the success of cancer therapeutics, off target cell toxicity prevails as one of the main challenges of cancer treatment. Exploration of drug delivery methods is a growing field of research, which involves a variety of materials and processing techniques. A natural polymer, gellan gum presents physicochemical properties that enable drug loading for sustained release in a broad range of environmental conditions and anatomical locations. Gellan gum is an anionic exopolysaccharide, produced via fermentation by , which gels in the presence of cations. Additionally, it is biocompatible and nontoxic. Multiple physical and chemical gelation processes have been reported for the use of gellan gum in drug delivery applications to produced varying form factors, including hydrogels, nanohydrogels, beads, films, or patches, with tunable mechanical and physicochemical properties. The resulting formulations have shown promising outcomes for drug delivery including improving drug bioavailability, drug solubility, and drug release over time, without compromising biocompatibility or the introduction of adverse effects. This review presents studies in which gellan gum has been processed to enable the delivery of antibiotics, antiallergens, anti-inflammatory, or antifungal molecules with a special focus on drugs for anticancer applications.
尽管癌症治疗取得了成功，但脱靶细胞毒性仍然是癌症治疗的主要挑战之一。药物递送方法的探索是一个不断发展的研究领域，涉及多种材料和加工技术。天然聚合物结冷胶具有物理化学性质，能够在广泛的环境条件和解剖位置实现药物负载以实现持续释放。结冷胶是一种阴离子胞外多糖，由发酵产生，在阳离子存在下会凝胶化。此外，它具有生物相容性且无毒。已经报道了多种物理和化学凝胶化过程，用于在药物递送应用中使用结冷胶以产生不同的形态因子，包括水凝胶、纳米水凝胶、珠子、薄膜或贴片，具有可调节的机械和物理化学性质。所得制剂在药物递送方面显示出有前景的结果，包括提高药物生物利用度、药物溶解度和随时间的药物释放，而不会损害生物相容性或引入不良反应。本综述介绍了将结冷胶加工以实现抗生素、抗过敏剂、抗炎或抗真菌分子递送的研究，特别关注抗癌应用的药物。
