Yanover L, Ellen R P
J Periodontol. 1986 Sep;57(9):562-7. doi: 10.1902/jop.1986.57.9.562.
A longitudinal study of 18 subjects progressing normally through puberty (Group 1) and a cross-sectional study of nine subjects with precocious puberty (Group 2) were undertaken to evaluate the effect of puberty on clinical and microbiologic parameters of periodontal health. The most inflamed first molar was selected for subgingival plaque sampling. There was no significant change in mean Plaque Index (PlI), Gingival Index (GI) or dark-field microscopic counts of the associated microflora in Group 1 from session to session. Individual subjects changing black pigmented Bacteroides (BPB) carrier status at a session also experienced a change in GI when compared to the group as a whole. A positive correlation was observed between GI and PlI at all sessions in the study. No radiographic evidence of destructive periodontal disease was observed. A correlation was noted between the presence, but not the levels, of BPB and plasma estradiol concentration in Group 2 subjects. Isolation of BPB, almost all B. intermedius, was not correlated with physical maturation in either group. During puberty, mild gingivitis may exist prior to detectable colonization by spirochetes or BPB. Hormonal events of puberty do not necessarily foster the colonization of pathogens implicated in adult periodontitis.
进行了一项对18名正常进入青春期的受试者（第1组）的纵向研究和一项对9名性早熟受试者（第2组）的横断面研究，以评估青春期对牙周健康的临床和微生物学参数的影响。选择炎症最严重的第一磨牙进行龈下菌斑采样。第1组各阶段之间的平均菌斑指数（PlI）、牙龈指数（GI）或相关微生物群的暗视野显微镜计数均无显著变化。与整个组相比，在某一阶段改变黑色色素类杆菌（BPB）携带者状态的个体受试者的GI也发生了变化。在该研究的所有阶段，GI和PlI之间均观察到正相关。未观察到牙周病破坏的影像学证据。在第2组受试者中，BPB的存在（而非水平）与血浆雌二醇浓度之间存在相关性。BPB（几乎都是中间类杆菌）的分离与两组中的身体成熟均无相关性。在青春期，在可检测到螺旋体或BPB定植之前，可能存在轻度牙龈炎。青春期的激素变化不一定促进与成人牙周炎相关的病原体的定植。
