Nakagawa S, Fujii H, Machida Y, Okuda K
Department of Pediatric Dentistry, Tokyo Dental College, Chiba, Japan.
J Clin Periodontol. 1994 Nov;21(10):658-65. doi: 10.1111/j.1600-051x.1994.tb00783.x.
A longitudinal study of 24 subjects progressing normally from prepuberty to puberty was undertaken to evaluate the effects of sex hormone levels on clinical and microbiologic parameters and on serum antibodies. During elementary school, at the beginning of the longitudinal monitoring, 2 groups, 12 subjects with gingivitis and 12 gingivitis-free subjects, were selected and observed through puberty. Bone ages and self-assessment of secondary sex characteristics were used to confirm puberty. A statistically significant increase in the proportions of Prevotella intermedia including Prevotella nigrescens and serum antibody levels against P. intermedia was seen in gingivitis group throughout the longitudinal study. Serum levels of testosterone in boys and estradiol and progesterone in girls was positively correlated with levels of P. intermedia and P. nigrescens. In puberty, a slight but significant increase in GI scores over prepuberty has been shown; however, there was no significant change in PlI from prepuberty to puberty. Our study confirmed that there was a statistically significant increase in gingival inflammation and in the proportion of P. intermedia and P. nigrescens in puberty relative to the baseline value, except in the gingivitis-free male group. Our findings suggest that these increases are correlated with elevation in systemic levels of the sex hormones.
对24名从青春期前正常进入青春期的受试者进行了一项纵向研究，以评估性激素水平对临床和微生物学参数以及血清抗体的影响。在小学阶段，即纵向监测开始时，选取了两组，一组12名患有牙龈炎的受试者和一组12名无牙龈炎的受试者，并对他们进行了整个青春期的观察。通过骨龄和第二性征的自我评估来确认青春期。在整个纵向研究中，牙龈炎组中包括变黑普雷沃菌在内的中间普雷沃菌比例和抗中间普雷沃菌血清抗体水平有统计学意义的增加。男孩的血清睾酮水平以及女孩的雌二醇和孕酮水平与中间普雷沃菌和变黑普雷沃菌的水平呈正相关。在青春期，牙龈指数（GI）评分相对于青春期前有轻微但显著的增加；然而，菌斑指数（PlI）从青春期前到青春期没有显著变化。我们的研究证实，相对于基线值，除了无牙龈炎的男性组外，青春期的牙龈炎症以及中间普雷沃菌和变黑普雷沃菌的比例有统计学意义的增加。我们的研究结果表明，这些增加与性激素全身水平的升高相关。
