三岁前儿童接受全身麻醉会增加患多动症的风险吗？
Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
作者信息
Song Junjie, Li Huifang, Wang Ying, Niu Chenguang
机构信息
Department of Anesthesiology, The First Affiliated Hospital of Henan University, Kaifeng, China.
Department of Medical Hospital, Henan University, Henan Medical Hospital, Henan University, Kaifeng, China.
出版信息
Front Psychiatry. 2021 Nov 24;12:717093. doi: 10.3389/fpsyt.2021.717093. eCollection 2021.
The objective of the study was to evaluate the relationship between frequency of exposure to general anesthesia before the age of 3 and subsequent risk of diagnosis for attention-deficit hyperactivity disorder (ADHD). We searched PubMed, Embase, Web of Science, and Cochrane Library database for eligible inclusion in the meta-analysis. The indicated outcomes were extracted from the included studies, and the combined effects were calculated using the RevMan software 5.3. Compared with no exposure to general anesthesia, single exposure to general anesthesia did not increase the risk of ADHD for children before the age of 3 [hazard ratio (HR): 1.14, 95%; confidence intervals (CI): 0.97-1.35; = 0.11; = 0%], while multiple exposures to general anesthesia did increase the risk of ADHD (HR: 1.83; 95% CIs: 1.00-3.32; = 0.05; = 81%). Multiple, but not single, exposures to general anesthesia in children before age of 3 increased the risk of ADHD.
该研究的目的是评估3岁前接受全身麻醉的频率与随后被诊断为注意力缺陷多动障碍（ADHD）的风险之间的关系。我们检索了PubMed、Embase、Web of Science和Cochrane图书馆数据库，以纳入符合条件的研究进行荟萃分析。从纳入的研究中提取指定的结果，并使用RevMan软件5.3计算合并效应。与未接受全身麻醉相比，3岁前儿童单次接受全身麻醉并未增加患ADHD的风险[风险比（HR）：1.14，95%；置信区间（CI）：0.97 - 1.35；P = 0.11；I² = 0%]，而多次接受全身麻醉确实增加了患ADHD的风险（HR：1.83；95% CI：1.00 - 3.32；P = 0.05；I² = 81%）。3岁前儿童多次而非单次接受全身麻醉会增加患ADHD的风险。
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