Department of Anesthesiology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Biomolecules. 2023 Nov 15;13(11):1654. doi: 10.3390/biom13111654.
Published evidence over the past few decades suggests that general anesthetics could be neurotoxins especially when administered at the extremes of age. The reported pathology is not only at the morphological level when examined in very young and aged brains, given that, importantly, newly developing evidence suggests a variety of behavioral impairments. Since anesthesia is unavoidable in certain clinical settings, we should consider the development of new anesthetics. A promising and safe solution could be a new family of anesthetics referred to as neuroactive steroids. In this review, we summarize the currently available evidence regarding their anesthetic and analgesic properties.
过去几十年的研究表明，全身麻醉剂可能是神经毒素，尤其是在极端年龄下使用时。报告的病理学不仅存在于非常年幼和年老的大脑的形态学水平上，而且重要的是，新的发展证据表明存在各种行为障碍。由于在某些临床情况下麻醉是不可避免的，因此我们应该考虑开发新的麻醉剂。一种有前途且安全的解决方案可能是一类新的麻醉剂，称为神经活性甾体。在这篇综述中，我们总结了目前关于它们的麻醉和镇痛特性的可用证据。
Zotero 插件