儿童缺铁性贫血与慢性化脓性中耳炎的关联：一项病例对照研究。
The association of iron deficiency anemia on chronic suppurative otitis media in children: A case-control study.
作者信息
Lasminingrum Lina, Purwanto Bambang, Sudiro Melati, Mutmainnah Anggie
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
出版信息
Ann Med Surg (Lond). 2021 Nov 23;72:103105. doi: 10.1016/j.amsu.2021.103105. eCollection 2021 Dec.
BACKGROUND
Chronic suppurative otitis media (CSOM) is the most common infectious disease in the world and the leading cause of hearing loss in children in developing countries. Iron deficiency anemia (IDA) is often found in children with CSOM.
OBJECTIVE
This study was conducted to determine the association between IDA and the incidence of CSOM in children.
METHOD
This research is a case-control study using consecutive sampling. Participants were divided into case group which are children diagnosed with CSOM (n = 42) and control group which are children with normal ear (n = 42). All participants were examined for serum iron (FE), hemoglobin (Hb), total iron-binding capacity (TIBC), and ferritin levels. The analysis used in this study includes the chi-square test or fisher extract test and independence -test or Man Whitney test with < 0.05.
RESULT
The measurement results obtained values of Hb (13.00 ± 1.34 g/dL; < 0.001), FE (95.13 ± 40.84 g/dL; < 0.001), TIBC (354.18 ± 62.44 g/dL; = 0.016), and ferritin levels (17.57 ± 8.55 g/dL; < 0.001). Participants who experienced IDA were 21.43% which in the case group was 31.0% and control group was 11.9% ( = 3.32; = 0.033).
CONCLUSION
IDA can increase the incidence of CSOM in children.
背景
慢性化脓性中耳炎（CSOM）是世界上最常见的传染病，也是发展中国家儿童听力损失的主要原因。缺铁性贫血（IDA）在CSOM患儿中经常被发现。
目的
本研究旨在确定IDA与儿童CSOM发病率之间的关联。
方法
本研究为采用连续抽样的病例对照研究。参与者分为病例组，即被诊断为CSOM的儿童（n = 42）和对照组，即耳部正常的儿童（n = 42）。对所有参与者进行血清铁（FE）、血红蛋白（Hb）、总铁结合力（TIBC）和铁蛋白水平的检测。本研究采用的分析方法包括卡方检验或费舍尔精确检验以及独立性检验或曼-惠特尼检验，P < 0.05。
结果
测量结果显示，Hb（13.00 ± 1.34 g/dL；P < 0.001）、FE（95.13 ± 40.84 g/dL；P < 0.001）、TIBC（354.18 ± 62.44 g/dL；P = 0.016）和铁蛋白水平（17.57 ± 8.55 g/dL；P < 0.001）。发生IDA的参与者占21.43%，其中病例组为31.0%，对照组为11.9%（P = 3.32；P = 0.033）。
结论
IDA可增加儿童CSOM的发病率。
Zotero 插件