Motamedi Maryam, Ajami Gholamhosein, Mohammadi Hamid, Amirhakimi Gholamhosein, Namdar Zahra Mehdipour, Ilkhani Homa, Moravej Hossein, Aslani Amir, Amirhakimi Anis
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Cardiovasc Echogr. 2021 Jul-Sep;31(3):165-170. doi: 10.4103/jcecho.jcecho_21_21. Epub 2021 Oct 26.
One of the most common endocrine disorders in children is diabetes which is the leading cause of premature cardiovascular disease in adulthood.
This study is aimed to investigate the extend of cardiac involvement in diabetic children by speckle tracking echocardiography (STE) in comparison to two-dimensional (2D) echocardiography and routine laboratory data.
A cross-sectional study conducted on patients under 18 years of age who deal with type one diabetes mellitus for more than 5 years.
To compare the STE results, we included the STE data of 25 normal age-matched children. All patients underwent laboratory analysis for lipid profile, blood sugar, and 2D echocardiography plus STE.
Two-sample independent -test, Chi-square test, logistic regression test, Spearman's rank correlation coefficient, and the Pearson correlation coefficient.
From March 2018 to 2019, we included 53 patients, mean age 15.8 ± 0.39 years and 52.8% female, and 25 nondiabetic control in this study. STE revealed global longitudinal strain (LS) -18.4 versus - 24.2 for patient (44 valid cases) versus control group, respectively, with significant statistical difference. Diabetic patients had lower LS in all segments compared to the control group.
STE has very high sensitivity to detect cardiac involvement far earlier than 2D echocardiography. None of the routine biomarkers or demographic features can predict cardiac involvement based on segmental abnormalities of STE. Active investigation to clear the remote impact of STE abnormalities and its practical role in childhood diabetes management is highly recommended.
糖尿病是儿童最常见的内分泌疾病之一，是成年期过早发生心血管疾病的主要原因。
本研究旨在通过斑点追踪超声心动图（STE）与二维（2D）超声心动图及常规实验室数据相比较，调查糖尿病儿童心脏受累的程度。
对18岁以下患1型糖尿病超过5年的患者进行横断面研究。
为比较STE结果，我们纳入了25名年龄匹配的正常儿童的STE数据。所有患者均接受了血脂、血糖实验室分析以及二维超声心动图加STE检查。
两样本独立t检验、卡方检验、逻辑回归检验、Spearman等级相关系数和Pearson相关系数。
从2018年3月至2019年，本研究纳入了53例患者，平均年龄15.8±0.39岁，女性占52.8%，以及25名非糖尿病对照者。STE显示，患者组（44例有效病例）与对照组的整体纵向应变（LS）分别为-18.4和-24.2，具有显著统计学差异。与对照组相比，糖尿病患者所有节段的LS均较低。
STE检测心脏受累的敏感性非常高，远比二维超声心动图更早。没有任何常规生物标志物或人口统计学特征能够基于STE的节段异常预测心脏受累情况。强烈建议积极开展研究以明确STE异常的远期影响及其在儿童糖尿病管理中的实际作用。
