Wang Qian, Yu Fei, Feng Ziqing, Li Weihua, Li Naiyang, Du Xinyue, Zhao Xuan, Li Saiqun, Yuan Jin
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Eye Center, Zhongshan City People's Hospital, Zhongshan, China.
Front Med (Lausanne). 2021 Nov 24;8:788302. doi: 10.3389/fmed.2021.788302. eCollection 2021.
To evaluate corneal elevation changes in patients with allergic conjunctivitis (AC) and to analyze their correlations with ocular allergy signs and corneal biomechanical alterations. Thirty patients (30 eyes) with AC and twenty normal subjects (20 eyes) were included in this prospective study. All participants underwent a complete ocular examination, including corneal tomography by Pentacam and corneal biomechanics evaluation by Corvis ST. AC patients were evaluated for their eye rubbing frequency and ocular allergic signs. The elevation at the thinnest location (TE) and the central location (CE), the elevation difference at the thinnest location (TED) and the central location (CED), and the mean value of elevation difference in the central 4 mm zoom (MED) of both the anterior and posterior corneal surface were significantly higher in the AC group than in the normal group ( < 0.05 for all). In AC patients, only anterior corneal elevation parameters were positively correlated with eye rubbing frequency and ocular allergy sign severity ( < 0.05 for all), while the tomography and biomechanical index (TBI) was positively correlated with the elevation parameters of both the anterior and posterior corneal surfaces ( < 0.05 for all). AC patients carry an increased risk of corneal ectasia. Posterior corneal elevation parameters are sensitive and reliable predictors of keratoconus (KC) risk in AC patients. https://clinicaltrials.gov/ct2/show/NCT04299399, identifier [NCT04299399].
评估过敏性结膜炎（AC）患者的角膜高度变化，并分析其与眼部过敏体征及角膜生物力学改变的相关性。本前瞻性研究纳入了30例AC患者（30只眼）和20例正常受试者（20只眼）。所有参与者均接受了全面的眼部检查，包括使用Pentacam进行角膜地形图检查以及使用Corvis ST进行角膜生物力学评估。对AC患者的揉眼频率和眼部过敏体征进行了评估。AC组前、后角膜表面最薄处（TE）和中央处（CE）的高度、最薄处（TED）和中央处（CED）的高度差以及中央4mm区域（MED）的高度差平均值均显著高于正常组（均P<0.05）。在AC患者中，仅前角膜高度参数与揉眼频率和眼部过敏体征严重程度呈正相关（均P<0.05），而地形图和生物力学指数（TBI）与前、后角膜表面的高度参数均呈正相关（均P<0.05）。AC患者发生角膜扩张的风险增加。后角膜高度参数是AC患者圆锥角膜（KC）风险的敏感且可靠的预测指标。https://clinicaltrials.gov/ct2/show/NCT04299399，标识符 [NCT04299399] 。
