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髋关节镜检查期间全层髋臼软骨瓣的治疗:骨髓抽吸浓缩物与微骨折术的比较

Treatment of Full-Thickness Acetabular Chondral Flaps During Hip Arthroscopy: Bone Marrow Aspirate Concentrate Versus Microfracture.

作者信息

Kucharik Michael P, Abraham Paul F, Nazal Mark R, Varady Nathan H, Eberlin Christopher T, Meek Wendy M, Naessig Sara A, Martin Scott D

机构信息

Sports Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Mass General Brigham, Boston, Massachusetts, USA.

Department of Orthopaedic Surgery, University of Southern California, Los Angeles, California, USA.

出版信息

Orthop J Sports Med. 2021 Dec 7;9(12):23259671211059170. doi: 10.1177/23259671211059170. eCollection 2021 Dec.

Abstract

BACKGROUND

The optimal treatment strategy for patients with full-thickness chondral flaps undergoing hip arthroscopy is controversial.

PURPOSE

To compare functional outcomes of patients who underwent bone marrow aspirate concentrate (BMAC) application with those of patients who underwent microfracture.

STUDY DESIGN

Cohort study; Level of evidence, 3.

METHODS

This was a retrospective case series of prospectively collected data on patients who underwent arthroscopic acetabular labral repair by 1 surgeon between June 2014 and April 2020. The inclusion criteria for this study were age ≥18 years, preoperative radiographs of the pelvis, arthroscopic acetabular labral repair, exposed subchondral bone with overlying chondral flap seen at the time of hip arthroscopy, microfracture or BMAC to address this lesion, and completed patient-reported outcome measures (PROMs) (International Hip Outcome Tool-33 [iHOT-33], Hip Outcome Score-Activities of Daily Living [HOS-ADL], Hip Outcome Score-Sports Subscale [HOS-Sport], modified Harris Hip Score [mHHS], and visual analog scale [VAS] for pain) at enrollment and 12-month follow-up. Clinical outcomes were assessed using PROM scores.

RESULTS

A total of 81 hips with full-thickness chondral flaps were included in this study: 50 treated with BMAC and 31 treated with microfracture. There were no significant differences between groups in age, sex, body mass index, tear size, radiographic osteoarthritis, or radiographic femoroacetabular impingement. In the BMAC cohort, all PROM scores improved significantly from preoperatively to follow-up: 41.7 to 75.6 for iHOT-33, 67.6 to 91.0 for HOS-ADL, 41.5 to 72.3 for HOS-Sport, 59.4 to 87.2 for mHHS, and 6.2 to 2.2 for VAS pain ( < .001 for all). In the microfracture cohort, the score improvements were 48.0 to 65.1 for iHOT-33 ( = .001), 80.5 to 83.3 for HOS-ADL ( = .275), 59.2 to 62.4 for HOS-Sport ( = .568), 70.4 to 78.3 for mHHS ( = .028), and 4.9 to 3.6 for VAS pain ( = .036). Regarding clinically meaningful outcomes, 77.6% of the BMAC group and 50.0% of the microfracture group met the minimal clinically important difference for iHOT-33 at the 12-month follow-up ( = .013).

CONCLUSION

Patients with full-thickness chondral flaps at the time of hip arthroscopy experienced greater improvements in functional outcome scores at the 12-month follow-up when treated with BMAC as opposed to microfracture.

摘要

背景

髋关节镜检查时全层软骨瓣患者的最佳治疗策略存在争议。

目的

比较接受骨髓抽吸浓缩物(BMAC)治疗的患者与接受微骨折治疗的患者的功能结局。

研究设计

队列研究;证据等级,3级。

方法

这是一项回顾性病例系列研究,前瞻性收集了2014年6月至2020年4月间由1名外科医生进行关节镜下髋臼盂唇修复的患者的数据。本研究的纳入标准为年龄≥18岁、术前骨盆X线片、关节镜下髋臼盂唇修复、髋关节镜检查时可见暴露的软骨下骨及上方的软骨瓣、采用微骨折或BMAC治疗该病变、以及在入组时和12个月随访时完成患者报告的结局指标(PROMs)(国际髋关节结局工具-33[iHOT-33]、髋关节结局评分-日常生活活动[HOS-ADL]、髋关节结局评分-运动子量表[HOS-Sport]、改良Harris髋关节评分[mHHS]和疼痛视觉模拟量表[VAS])。使用PROM评分评估临床结局。

结果

本研究共纳入81例全层软骨瓣的髋关节:50例接受BMAC治疗,31例接受微骨折治疗。两组在年龄、性别、体重指数、撕裂大小、影像学骨关节炎或影像学股骨髋臼撞击症方面无显著差异。在BMAC队列中,所有PROM评分从术前到随访均显著改善:iHOT-33从41.7提高到75.6,HOS-ADL从67.6提高到91.0,HOS-Sport从41.5提高到72.3,mHHS从59.4提高到87.2,VAS疼痛从6.2降低到2.2(所有均P<0.001)。在微骨折队列中,iHOT-33评分从48.0提高到65.1(P = 0.001),HOS-ADL从80.5提高到83.3(P = 0.275),HOS-Sport从59.2提高到62.4(P = 0.568),mHHS从70.4提高到78.3(P = 0.028),VAS疼痛从4.9降低到3.6(P = 0.036)。关于具有临床意义的结局,在12个月随访时,BMAC组77.6%的患者和微骨折组50.0%的患者达到了iHOT-33的最小临床重要差异(P = 0.013)。

结论

髋关节镜检查时存在全层软骨瓣的患者,与微骨折治疗相比,接受BMAC治疗在12个月随访时功能结局评分改善更大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7558/8655470/e96290993728/10.1177_23259671211059170-fig1.jpg

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