Battaglia Parodi Maurizio, Arrigo Alessandro, Pina Adelaide, Calcagno Francesca, Antropoli Alessio, Hassan Farah Rashid, Bandello Francesco, Mansour Ahmad M
Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.
Department of Ophthalmology, American University of Beirut, Rafic Hariri University Hospital, P.O. Box 113-6044, Beirut, Lebanon.
Am J Ophthalmol Case Rep. 2021 Nov 26;24:101235. doi: 10.1016/j.ajoc.2021.101235. eCollection 2021 Dec.
Sclerochoroidal calcifications (SCC) are rare conditions characterized by unifocal or multifocal well-defined scleral deposits of calcium. The present study describes two cases of SCC complicated by the onset of choroidal neovascularization (CNV).
Five patients affected by SCC were enrolled in the study and two cases were complicated by CNV. Both patients underwent complete ophthalmic examination with multimodal imaging including optical coherence tomography angiography (OCTA).
In the two patients with CNV (1 male), BCVA was 20/40 and 20/50 in the affected eyes. Fundus examination revealed an irregular yellow-white lesion close to the superotemporal arcade in both patients, with exudation. The diagnosis of CNV was performed by means of fluorescein angiography in one patient and OCTA in the other patient. The patients received a total of 3 and 9 ranibizumab injections respectively over a six-year follow-up, reaching a final BCVA of 20/25 in both patients with stabilization of the CNV.
SCC may be complicated by CNV, with good management obtained by intravitreal anti-VEGF injections.
巩膜脉络膜钙化（SCC）是一种罕见的疾病，其特征为单灶或多灶界限清晰的巩膜钙沉积。本研究描述了2例并发脉络膜新生血管（CNV）的SCC病例。
5例SCC患者纳入本研究，其中2例并发CNV。2例患者均接受了包括光学相干断层扫描血管造影（OCTA）在内的多模式成像的全面眼科检查。
2例CNV患者（1例男性）患眼的最佳矫正视力（BCVA）分别为20/40和20/50。眼底检查发现2例患者均在颞上弓附近有不规则黄白色病变，并伴有渗出。1例患者通过荧光素血管造影诊断CNV，另1例通过OCTA诊断。在6年的随访中，2例患者分别接受了3次和9次雷珠单抗注射，最终2例患者的BCVA均达到20/25，CNV稳定。
SCC可能并发CNV，玻璃体腔内注射抗血管内皮生长因子（VEGF）可获得良好的治疗效果。
