Hickey Aobha, Pardo Leticia M, Reen F Jerry, McGlacken Gerard P
School of Chemistry, Analytical and Biological Chemistry Research Facility, School of Microbiology, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Cork T12 YN60, Ireland.
ACS Omega. 2021 Nov 22;6(48):33141-33148. doi: 10.1021/acsomega.1c05508. eCollection 2021 Dec 7.
Individual bacteria communicate by the release and interpretation of small molecules, a phenomenon known as quorum sensing (QS). We hypothesized that QS compounds extruded by could be interpreted by -a form of interspecies communication. We interrogate the structure-activity relationship within the recently discovered pyrone QS network and reveal the exquisite structural features required for targeted phenotypic behavior. The interruption of QS is an exciting, nonbiocidal approach to tackling infection, and understanding its nuances can only be achieved by studies such as this.
单个细菌通过释放和解读小分子进行通信，这一现象被称为群体感应（QS）。我们推测，由[具体细菌名称1]分泌的QS化合物可能会被[具体细菌名称2]解读——这是一种种间通信形式。我们研究了最近发现的吡喃酮QS网络中的构效关系，并揭示了靶向表型行为所需的精细结构特征。干扰群体感应是一种令人兴奋的、非杀菌性的抗感染方法，只有通过这样的研究才能理解其细微差别。
