Shivakumar Koushik, Rajalakshmi A R, Jha Kirti Nath, Nagarajan Swathi, Srinivasan A R, Lokesh Maran A
Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pondicherry, India.
Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pondicherry UT 607402, India.
Ther Adv Ophthalmol. 2021 Dec 5;13:25158414211056385. doi: 10.1177/25158414211056385. eCollection 2021 Jan-Dec.
Magnesium has an essential role in glucose metabolism, and hypomagnesaemia is common in diabetes mellitus. However, the relationship between serum magnesium and diabetic retinopathy is poorly understood.
To determine the association between serum magnesium levels and retinopathy in type 2 diabetic patients with normal renal function and to correlate it with severity of retinopathy.
This cross-sectional observational study was conducted in a semi-urban tertiary-care teaching hospital. Clinicodemographic profile and serum magnesium levels were determined in patients with type 2 diabetes mellitus (DM) with (group 1) and without (group 2) retinopathy. Serum magnesium levels were correlated with the presence and severity of retinopathy.
Of 104 type 2 DM patients, 50 had retinopathy. Younger age, longer duration of disease and poorer glycaemic control ( < 0.05) were found to be associated with retinopathy. The mean serum magnesium levels in patients with retinopathy and those without retinopathy were 1.63 ± 0.30 mg/dL and 1.76 ± 0.22 mg/dL, respectively ( = 0.029). Reduced serum magnesium was associated with elevated fasting sugars ( = 0.019) and female gender ( = 0.037). On comparative analysis of patients with sight-threatening diabetic retinopathy (STDR), non-STDR and no retinopathy by ANOVA test, patients with STDR had significantly lower serum magnesium (1.55 ± 0.33 mg/dL) ( = 0.031).
Serum magnesium levels were lower in patients with diabetic retinopathy. Patients with STDR had lower serum magnesium compared with those without STDR.
Serum magnesium, studied extensively for its role in glucose metabolism, was found to be lower in patients with diabetic retinopathy compared with those without retinopathy. Sight-threatening diabetic retinopathy had significantly lower levels of serum magnesium.
镁在葡萄糖代谢中起重要作用，低镁血症在糖尿病患者中很常见。然而，血清镁与糖尿病视网膜病变之间的关系尚不清楚。
确定肾功能正常的2型糖尿病患者血清镁水平与视网膜病变之间的关联，并将其与视网膜病变的严重程度相关联。
这项横断面观察性研究在一家半城市三级护理教学医院进行。在患有（第1组）和未患有（第2组）视网膜病变的2型糖尿病（DM）患者中确定临床人口统计学特征和血清镁水平。血清镁水平与视网膜病变的存在和严重程度相关。
在104例2型糖尿病患者中，50例患有视网膜病变。发现年龄较小、病程较长和血糖控制较差（<0.05）与视网膜病变有关。患有视网膜病变和未患有视网膜病变的患者的平均血清镁水平分别为1.63±0.30mg/dL和1.76±0.22mg/dL（P=0.029）。血清镁降低与空腹血糖升高（P=0.019）和女性（P=0.037）有关。通过方差分析对有威胁视力的糖尿病视网膜病变（STDR）、非STDR和无视网膜病变的患者进行比较分析，STDR患者的血清镁显著较低（1.55±0.33mg/dL）（P=0.031）。
糖尿病视网膜病变患者的血清镁水平较低。与没有STDR的患者相比，患有STDR的患者血清镁较低。
血清镁因其在葡萄糖代谢中的作用而被广泛研究，发现糖尿病视网膜病变患者的血清镁低于无视网膜病变的患者。有威胁视力的糖尿病视网膜病变的血清镁水平显著较低。
