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精神分裂症和重度抑郁症患者的阴性症状与努力折扣之间的关联。

Associations Between Negative Symptoms and Effort Discounting in Patients With Schizophrenia and Major Depressive Disorder.

作者信息

Cathomas Flurin, Klaus Federica, Guetter Karoline, Seifritz Erich, Hartmann-Riemer Matthias N, Tobler Philippe N, Kaiser Stefan, Kaliuzhna Mariia

机构信息

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Schizophr Bull Open. 2021 Jun 11;2(1):sgab022. doi: 10.1093/schizbullopen/sgab022. eCollection 2021 Jan.

DOI:10.1093/schizbullopen/sgab022
PMID:34901865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8650075/
Abstract

Deficits in goal-directed decision making and motivation are hallmark characteristics of several neuropsychiatric disorders, including schizophrenia (SZ) and major depressive disorder (MDD). Studies using effort-based decision-making tasks have shown that both patients with SZ and MDD invest less physical effort in order to obtain rewards. However, how these motivational deficits relate to clinically assessed symptom dimensions such as apathy remains controversial. Using a grip-strength-based effort discounting task we assessed effort-based decision-making behavior in healthy controls (HC) ( = 18), patients with SZ ( = 42), and MDD ( = 44). We then investigated how effort discounting relates to different symptom dimensions. There were no differences in effort discounting between HC participants and patients with SZ or MDD. In addition, we did not observe a correlation between effort discounting and negative symptoms (NS) in patients with SZ or MDD. In conclusion, the current study does not support an association between effort discounting and NS in SZ or MDD. Further studies are needed to investigate effort discounting and its relation to psychopathological dimensions across different neuropsychiatric disorders.

摘要

目标导向决策和动机方面的缺陷是包括精神分裂症（SZ）和重度抑郁症（MDD）在内的几种神经精神疾病的标志性特征。使用基于努力的决策任务的研究表明，SZ患者和MDD患者为了获得奖励投入的体力努力都较少。然而，这些动机缺陷与诸如冷漠等临床评估的症状维度之间的关系仍存在争议。我们使用基于握力的努力折扣任务，评估了健康对照（HC）（n = 18）、SZ患者（n = 42）和MDD患者（n = 44）基于努力的决策行为。然后，我们研究了努力折扣与不同症状维度之间的关系。HC参与者与SZ患者或MDD患者在努力折扣方面没有差异。此外，我们在SZ患者或MDD患者中未观察到努力折扣与阴性症状（NS）之间的相关性。总之，当前研究不支持SZ或MDD中努力折扣与NS之间存在关联。需要进一步研究来调查努力折扣及其与不同神经精神疾病中精神病理维度的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/2696b98689a7/sgab022_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/c9c724e083c4/sgab022_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/d35fce6ec111/sgab022_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/56b9450636f3/sgab022_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/8525f07f8f38/sgab022_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/2696b98689a7/sgab022_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/c9c724e083c4/sgab022_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/d35fce6ec111/sgab022_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/56b9450636f3/sgab022_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/8525f07f8f38/sgab022_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c771/8650075/2696b98689a7/sgab022_fig5.jpg

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