特应性皮炎中针对饮食抗原的体液免疫。II. IgE和IgG亚类抗体分析。

Humoral immunity to dietary antigens in atopic dermatitis. II. Analysis of IgE and IgG subclass antibodies.

作者信息

Husby S, Larsen F S, Ahlstedt S, Svehag S E

出版信息

Allergy. 1986 Jul;41(5):386-91. doi: 10.1111/j.1398-9995.1986.tb00317.x.

DOI:10.1111/j.1398-9995.1986.tb00317.x

Abstract

IgG subclass antibodies to two dietary antigens, ovalbumin (OA) and beta-lactoglobulin (BLG) were measured with quantitative ELISA-techniques in 16 patients with atopic dermatitis (AD) (6-21 years old) and closely matched controls. In addition, IgE-antibodies to OA, BLG and milk were determined with RAST. IgG subclass antibodies were frequently detected in IgG1 and IgG4 for both AD-patients and controls, quantitatively dominated by IgG4. The IgG4 anti-BLG antibody levels were significantly higher (P less than 0.001) in AD-patients (median: 1.1 microgram/ml, range: 0-24.0 microgram/ml) than in controls (median: 0.05 microgram/ml, range: 0-1.05 microgram/ml). No relation was found between IgG4 anti-BLG antibody levels, levels of IgE antibodies to milk or BLG, or severity of disease.

摘要

采用定量酶联免疫吸附测定技术，对16例特应性皮炎（AD）患者（6至21岁）及年龄匹配的对照者检测了针对两种饮食抗原卵清蛋白（OA）和β-乳球蛋白（BLG）的IgG亚类抗体。此外，采用放射变应原吸附试验（RAST）测定了针对OA、BLG和牛奶的IgE抗体。AD患者和对照者的IgG1和IgG4中均频繁检测到IgG亚类抗体，以IgG4在数量上占主导。AD患者中IgG4抗BLG抗体水平（中位数：1.1微克/毫升，范围：0至24.0微克/毫升）显著高于对照者（中位数：0.05微克/毫升，范围：0至1.05微克/毫升）（P<0.001）。未发现IgG4抗BLG抗体水平、针对牛奶或BLG的IgE抗体水平与疾病严重程度之间存在关联。