Husby S, Schultz Larsen F, Svehag S E
Department of Dermatology, Odense University Hospital, Denmark.
Acta Derm Venereol Suppl (Stockh). 1989;144:88-92. doi: 10.2340/000155551448892.
The role of IgG subclasses and IgG subclass antibodies in atopic disease is controversial. Serum IgG and IgG subclass (IgG1-4) antibodies to the two dietary antigens ovalbumin (OA) and beta-lactoglobulin (BLG) were measured with ELISA-methods in 16 patients with mild or moderate atopic dermatitis (AD) and healthy controls. The IgG antibodies were measured in 31 patients with previous AD and controls. The IgG subclass antibodies to OA and BLG showed predominance of IgG4 and IgG1 for both patients and controls. The levels of IgG and IgG subclass antibodies to OA did not differ between the groups, but the levels of IgG and IgG4 anti-BLG antibody were higher in patients with active AD than in controls. The antibody levels did not correlate with severity of disease or with a history of food allergy/intolerance. IgG4 antibodies to dietary antigens may be elevated in AD, but the diagnostic significance of IgG subclass antibody measurement is limited.
IgG亚类及IgG亚类抗体在特应性疾病中的作用存在争议。采用酶联免疫吸附测定法（ELISA法）检测了16例轻、中度特应性皮炎（AD）患者及健康对照者血清中针对两种饮食抗原卵清蛋白（OA）和β-乳球蛋白（BLG）的IgG及IgG亚类（IgG1 - 4）抗体。对31例既往有AD病史的患者及对照者检测了IgG抗体。患者和对照者针对OA和BLG的IgG亚类抗体均显示以IgG4和IgG1为主。两组间针对OA的IgG及IgG亚类抗体水平无差异，但活动期AD患者针对BLG的IgG及IgG4抗体水平高于对照者。抗体水平与疾病严重程度或食物过敏/不耐受史无关。AD患者中针对饮食抗原的IgG4抗体可能升高，但IgG亚类抗体检测的诊断意义有限。
