Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 Japan.
Hell J Nucl Med. 2021 Sep-Dec;24(3):199-205. doi: 10.1967/s002449912403. Epub 2021 Dec 17.
To determine whether results of a standardized uptake value (SUV)-based semi-quantitative analytic method for gallium-67 (Ga)-citrate single photon emission tomography/computed tomography (SPECT/CT) reflects disease activity in patients with interstitial lung disease.
Gallium-67-citrate SPECT/CT was used to evaluate disease activity in 24 patients with interstitial pneumoniaon clinical grounds at a single institution from June 2018 to August 2020. SUV in a given volume of interest over the bilateral pulmonary parenchyma was calculated using a dosimetry software package. Correlations of maximum SUV (SUVmax) and mean SUV (SUVmean) with clinical factors, including KL-6, lactate dehydrogenase (LDH), and C-reactive protein (CRP), were evaluated in all 24, as well as in 15 patients with spirometry results using Pearson's rank correlation test.
The mean bilateral pulmonary SUVmax value showed a moderately significant correlation with KL-6 (Pearson's correlation coefficient r=0.51, P=0.012) and LDH (r=0.51, P=0.010), a weak non-significant correlation with DLCO% (r=-0.26, P=0.34), and no correlation with CRP (r=-0.01, P=0.94), FVC% (r=0.11, P=0.71), or FEV1.0% (r=0.14, P=0.62). Eleven patients with high KL-6 (≥1000U/mL) were defined as having disease activity. Maximum SUV sensitivity, specificity, and accuracy for predicting interstitial lung disease activity were 72.7%, 76.9%, and 75.0%, respectively, with a best cut-off value of 3.78.
Semi-quantitative values obtained with Ga-citrate SPECT/CT showed a moderate correlation with KL-6 and moderate diagnostic performance for predicting disease activity of interstitial lung disease. It is rather unlikely that quantitative Ga-citrate SPECT/CT will have a role into the algorithm of interstitial lung disease.
确定基于锝-67（Ga）-枸橼酸盐单光子发射断层扫描/计算机断层扫描（SPECT/CT）的标准化摄取值（SUV）的半定量分析方法的结果是否反映了间质性肺病患者的疾病活动。
2018 年 6 月至 2020 年 8 月，在一家机构中，根据临床情况，使用 Ga-枸橼酸盐 SPECT/CT 评估 24 例间质性肺炎患者的疾病活动。使用剂量学软件包计算双侧肺实质中给定感兴趣区的 SUV。使用 Pearson 等级相关检验评估 SUVmax 和 SUVmean 与临床因素（包括 KL-6、乳酸脱氢酶（LDH）和 C-反应蛋白（CRP））之间的相关性，在所有 24 例患者以及 15 例具有肺功能检查结果的患者中进行。
平均双侧肺 SUVmax 值与 KL-6（Pearson 相关系数 r=0.51，P=0.012）和 LDH（r=0.51，P=0.010）呈中度显著相关，与 DLCO%（r=-0.26，P=0.34）呈弱非显著相关，与 CRP（r=-0.01，P=0.94）、FVC%（r=0.11，P=0.71）或 FEV1.0%（r=0.14，P=0.62）无相关性。将 KL-6（≥1000U/mL）较高的 11 例患者定义为有疾病活动。SUVmax 对预测间质性肺病活动的敏感性、特异性和准确性分别为 72.7%、76.9%和 75.0%，最佳截断值为 3.78。
Ga-枸橼酸盐 SPECT/CT 获得的半定量值与 KL-6 呈中度相关，对预测间质性肺病的疾病活动具有中等诊断性能。定量 Ga-枸橼酸盐 SPECT/CT 不太可能在间质性肺病的算法中发挥作用。
