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镓-枸橼酸盐闪烁显像在肾炎处理中的定量评估。

Quantitative evaluation of Ga-citrate scintigraphy in the management of nephritis.

机构信息

Department of Radiology, Tokushima University Hospital, Kuramoto-cho 2-50-1, Tokushima, 770-8503, Japan.

Department of Medical Imaging/Nuclear Medicine, Tokushima University Graduate School of Biomedical Sciences, Kuramoto-cho 3-18-15, Tokushima, Tokushima, 770-8503, Japan.

出版信息

Sci Rep. 2024 Jul 15;14(1):16313. doi: 10.1038/s41598-024-66823-2.

DOI:10.1038/s41598-024-66823-2
PMID:39009630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250846/
Abstract

In Ga-citrate scintigraphy (Ga-S), visual assessment is used by evaluating renal-uptake comparison with liver and spine and is simple and objective. We adopted the standardized uptake value (SUV) for Ga-citrate and proposed two quantitative indices, active nephritis volume (ANV) and total nephritis uptake (TNU). This study clarified the utility of new Ga-S-based quantitative indices in nephritis management. Before SUV measurement, the Becquerel calibration factor of Ga-citrate was obtained using a phantom experiment. Seventy patients who underwent SPECT/CT imaging were studied. SUV, ANV, and TNU were calculated using a quantitative analysis software for bone SPECT. SUV, ANV, and TNU were analyzed using the (1) threshold method (set 40%) and constant-value method for (2) vertebral SUV, and (3) vertebral SUV. ROC analysis was used to evaluate SUV, ANV, and TNU diagnostic abilities to distinguish nephritis presence and absence as well as interstitial nephritis (IN) and non-IN. The area under the curve (AUC) for nephritis presence or absence had a good value (0.80) for SUV (1), ANV (3), and TNU (3). The AUC for differentiation between IN and non-IN groups had a good value (0.80) for SUV (1). Thus, the new Ga-S-based quantitative indices were useful to evaluate nephritis and distinguish IN and non-IN.

摘要

在镓 - 枸橼酸盐闪烁显像（Ga-S）中，通过评估与肝脏和脊柱的肾摄取比较来进行视觉评估，既简单又客观。我们采用了镓 - 枸橼酸盐的标准化摄取值（SUV），并提出了两个定量指标，即活动性肾炎体积（ANV）和总肾炎摄取（TNU）。本研究阐明了基于新 Ga-S 的定量指标在肾炎管理中的应用。在 SUV 测量之前，使用体模实验获得了 Ga-枸橼酸盐的贝克勒尔校准因子。对 70 例接受 SPECT/CT 成像的患者进行了研究。使用骨 SPECT 的定量分析软件计算了 SUV、ANV 和 TNU。使用（1）阈值法（设定为 40%）和（2）椎体 SUV 的常数值法以及（3）椎体 SUV 分析了 SUV、ANV 和 TNU。使用 ROC 分析评估了 SUV、ANV 和 TNU 区分肾炎存在和不存在以及间质性肾炎（IN）和非-IN 的诊断能力。SUV（1）、ANV（3）和 TNU（3）的肾炎存在或不存在的曲线下面积（AUC）值较好（0.80）。SUV（1）区分 IN 和非-IN 组的 AUC 值较好（0.80）。因此，基于新 Ga-S 的定量指标可用于评估肾炎并区分 IN 和非-IN。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/a9718438ff0b/41598_2024_66823_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/c1dd800dd410/41598_2024_66823_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/8cf309c59d52/41598_2024_66823_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/722cd95041e3/41598_2024_66823_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/09c8b7961163/41598_2024_66823_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/0b31e46cec2d/41598_2024_66823_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/ef401cfb4f26/41598_2024_66823_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/a9718438ff0b/41598_2024_66823_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/c1dd800dd410/41598_2024_66823_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/8cf309c59d52/41598_2024_66823_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/fcd939ebe306/41598_2024_66823_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/722cd95041e3/41598_2024_66823_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/09c8b7961163/41598_2024_66823_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/0b31e46cec2d/41598_2024_66823_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/ef401cfb4f26/41598_2024_66823_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abcb/11250846/a9718438ff0b/41598_2024_66823_Fig8_HTML.jpg

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