Lewin H A, Bernoco D
Anim Genet. 1986;17(3):197-207. doi: 10.1111/j.1365-2052.1986.tb03191.x.
The role of the bovine major histocompatibility complex in bovine leukaemia virus (BLV) infection and disease progression was investigated in a herd of Shorthorn cattle (n = 117). The frequency of cows that were seropositive to BLV-glycoprotein antigen was 51%. Twenty-three per cent of the seropositive cows were lymphocytotic. At the herd level, relative resistance to BLV-dependent B-cell proliferation and lymphocytosis among seropositive cows was associated with bovine lymphocyte antigen (BoLA)-DA7, whereas susceptibility was associated with BoLA-DA12.3. These associations were also confirmed at the family level, where BoLA phenotypes were used as haplotypic markers. Among the offspring of one BoLA-heterozygous sire (n = 33), resistance segregated with the DA7 haplotype and susceptibility with the DA12.3 haplotype. In this sire group, maternal transmission of the BoLA-w8 allele was associated with increased susceptibility to B-cell proliferation and lymphocytosis in w8/DA12.3 heterozygotes. These data provide the first evidence that subclinical progression of BLV infection is under the control of the BoLA complex, and suggest that the BoLA system can be used to select for resistance to B-cell proliferation and the development of lymphocytosis in BLV-infected herds.
在一群短角牛（n = 117）中，研究了牛主要组织相容性复合体在牛白血病病毒（BLV）感染和疾病进展中的作用。对BLV糖蛋白抗原呈血清阳性的奶牛频率为51%。23%的血清阳性奶牛出现淋巴细胞增多。在牛群水平上，血清阳性奶牛中对BLV依赖的B细胞增殖和淋巴细胞增多的相对抗性与牛淋巴细胞抗原（BoLA）-DA7相关，而易感性与BoLA-DA12.3相关。这些关联在家族水平上也得到了证实，在家族水平上，BoLA表型被用作单倍型标记。在一头BoLA杂合公牛的后代（n = 33）中，抗性与DA7单倍型相关，易感性与DA12.3单倍型相关。在这个公牛组中，BoLA-w8等位基因的母系遗传与w8/DA12.3杂合子中B细胞增殖和淋巴细胞增多的易感性增加有关。这些数据首次证明了BLV感染的亚临床进展受BoLA复合体的控制，并表明BoLA系统可用于选择对BLV感染牛群中B细胞增殖和淋巴细胞增多的抗性。
