Stear M J, Dimmock C K, Newman M J, Nicholas F W
Department of Immunology, John Curtin School of Medical Research, Australian National University, ACT.
Anim Genet. 1988;19(2):151-8. doi: 10.1111/j.1365-2052.1988.tb00800.x.
The association between bovine major histocompatibility system (BoLA) type and persistent lymphocytosis in cattle with antibodies to bovine leukaemia virus was examined by comparing antigen frequencies in cattle with persistent lymphocytosis to controls matched for age, sex, breed and presence of antibodies to BLV. The cattle came from nine dairy herds in south-east Queensland, Australia; six herds were Australian Illawarra Shorthorn (AIS), two herds were Jersey and one herd was Friesian. Antigen W6 and Eu28R were more common in cattle with persistent lymphocytosis than in controls. Antigen W8 was less common in AIS cattle with persistent lymphocytosis. A study of 24 offspring from one sire, heterozygous for W10 and Eu28R, showed that offspring inheriting Eu28R from the sire were significantly more likely to have antibodies to BLV than offspring inheriting the opposing W10 haplotype.
通过比较持续淋巴细胞增多症牛与年龄、性别、品种及牛白血病病毒（BLV）抗体存在情况相匹配的对照牛的抗原频率，研究了牛主要组织相容性系统（BoLA）类型与感染BLV且患有持续淋巴细胞增多症的牛之间的关联。这些牛来自澳大利亚昆士兰州东南部的九个奶牛场；六个牛场的牛是澳大利亚伊拉瓦拉短角牛（AIS），两个牛场的是泽西牛，一个牛场的是弗里斯兰牛。抗原W6和Eu28R在患有持续淋巴细胞增多症的牛中比在对照牛中更常见。抗原W8在患有持续淋巴细胞增多症的AIS牛中较少见。对一头W10和Eu28R杂合的公牛的24个后代进行的研究表明，从父亲那里继承Eu28R的后代比继承相反W10单倍型的后代更有可能感染BLV。
