Noyes J, Woodmansee D, Chervinsky P
Ann Allergy. 1986 Oct;57(4):273-5.
Thirty-one of 75 patients with recurrent upper respiratory infections were found to have immunoglobulin G subclass deficiencies with normal levels of total immunoglobulin G in a clinical allergy and asthma practice. Sixteen were IgG3 deficient, thirteen IgG2 deficient, and two were IgG1 deficient. Only one patient had an IgA deficiency. Two patients have normal IgG with decreased PRP titers. Serum antibody titers to the capsular polysaccharide of Haemophilus influenzae type B (HibCP) were found to be low in seven patients. Other investigators have established relationships between these deficiencies and recurrent infections. When investigating patients with recurrent infections, it seems prudent to look beyond simple quantitative immunoglobulins.
在一家临床过敏与哮喘诊所中，75例复发性上呼吸道感染患者中有31例被发现存在免疫球蛋白G亚类缺陷，而总免疫球蛋白G水平正常。16例患者存在IgG3缺陷，13例存在IgG2缺陷，2例存在IgG1缺陷。只有1例患者存在IgA缺陷。2例患者免疫球蛋白G正常但肺炎球菌多糖滴度降低。7例患者的B型流感嗜血杆菌（HibCP）荚膜多糖血清抗体滴度较低。其他研究人员已确定了这些缺陷与复发性感染之间的关系。在调查复发性感染患者时，似乎谨慎的做法是不仅仅关注简单的定量免疫球蛋白。
