Lillja Johan, Lanekoff Ingela
Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.
Methods Mol Biol. 2022;2437:241-249. doi: 10.1007/978-1-0716-2030-4_17.
Nanospray desorption electrospray ionization (nano-DESI) is a technique that can be used for mass spectrometry imaging (MSI) experiments. Due to the separation of sampling and ionization events, the nano-DESI solvent can be doped with additives to alter the specificity and selectivity of the experiment. In this chapter, we describe the addition of silver ions to the nano-DESI solvent for increased specificity and sensitivity of double bond containing analyte molecules for nano-DESI MSI.
纳米喷雾解吸电喷雾电离（nano-DESI）是一种可用于质谱成像（MSI）实验的技术。由于采样和电离过程的分离，nano-DESI溶剂可掺杂添加剂以改变实验的特异性和选择性。在本章中，我们描述了向nano-DESI溶剂中添加银离子，以提高nano-DESI MSI对含双键分析物分子的特异性和灵敏度。
