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霍乱弧菌中的质粒青霉素耐药性：新型β-内酰胺酶SAR-1的鉴定

Plasmid penicillin resistance in Vibrio cholerae: identification of new beta-lactamase SAR-1.

作者信息

Reid A J, Amyes S G

出版信息

Antimicrob Agents Chemother. 1986 Aug;30(2):245-7. doi: 10.1128/AAC.30.2.245.

DOI:10.1128/AAC.30.2.245
PMID:3490216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180527/
Abstract

Two strains of Vibrio cholerae biotype El Tor, isolated in Tanzania, possessed a single IncC resistance plasmid of 113 kilobases. Both plasmids encoded the production of a novel beta-lactamase, SAR-1, which was 33,700 daltons in size and was able to hydrolyze carbenicillin as well as penicillin G. The SAR-1 beta-lactamase was quite distinct from all other plasmid beta-lactamases by virtue of its unusually low isoelectric point and a combination of its size, substrate profile, and inhibition properties. This enzyme is only the second beta-lactamase identified in V. cholerae species and the first to be reported in V. cholerae strains isolated in Southern Africa.

摘要

在坦桑尼亚分离出的两株霍乱弧菌生物型埃尔托菌株，拥有一个113千碱基的单一IncC耐药质粒。这两种质粒都编码一种新型β-内酰胺酶SAR-1的产生，其大小为33700道尔顿，能够水解羧苄青霉素以及青霉素G。SAR-1β-内酰胺酶由于其异常低的等电点以及其大小、底物谱和抑制特性的组合，与所有其他质粒β-内酰胺酶截然不同。这种酶是在霍乱弧菌种中鉴定出的第二种β-内酰胺酶，也是在南部非洲分离出的霍乱弧菌菌株中首次报道的β-内酰胺酶。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa7/180527/5cb71e0c528c/aac00163-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa7/180527/5cb71e0c528c/aac00163-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa7/180527/5cb71e0c528c/aac00163-0062-a.jpg

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Development of test panel of beta-lactamases expressed in a common Escherichia coli host background for evaluation of new beta-lactam antibiotics.在常见大肠杆菌宿主背景中表达的β-内酰胺酶检测板的开发，用于评估新型β-内酰胺类抗生素。
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