Department of General Surgery, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China.
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei 230022, China.
Math Biosci Eng. 2022 Jan;19(1):169-190. doi: 10.3934/mbe.2022009. Epub 2021 Nov 9.
Plasmacytoma variant translocation 1 (PVT1) is involved in multiple signaling pathways and plays an important regulatory role in a variety of malignant tumors. However, its role in the prognosis and immune invasion of bladder urothelial carcinoma (BLCA) remains unclear. This study investigated the expression of PVT1 in tumor tissue and its relationship with immune invasion, and determined its prognostic role in patients with BLCA. Patients were identified from the cancer genome atlas (TCGA). The enrichment pathway and function of PVT1 were explained by gene ontology (GO) term analysis, gene set enrichment analysis (GSEA) and single-sample gene set enrichment analysis (ssGSEA), and the degree of immune cell infiltration was quantified. Kaplan-Meier analysis and Cox regression were used to analyze the correlation between PVT1 and survival rate. PVT1-high BLCA patients had a lower 10-year disease-specific survival (DSS P < 0.05) and overall survival (OS P < 0.05). Multivariate Cox regression analysis showed that PVT1 (high vs. low) (P = 0.004) was an independent prognostic factor. A nomogram was used to predict the effect of PVT1 on the prognosis. PVT1 plays an important role in the progression and prognosis of BLCA and can be used as a medium biomarker to predict survival after cystectomy.
浆细胞瘤变异易位 1（PVT1）参与多种信号通路，在多种恶性肿瘤中发挥重要的调控作用。然而，其在膀胱尿路上皮癌（BLCA）中的预后和免疫浸润作用尚不清楚。本研究探讨了 PVT1 在肿瘤组织中的表达及其与免疫浸润的关系，并确定了其在 BLCA 患者预后中的作用。患者从癌症基因组图谱（TCGA）中确定。通过基因本体论（GO）术语分析、基因集富集分析（GSEA）和单样本基因集富集分析（ssGSEA）解释 PVT1 的富集途径和功能，并量化免疫细胞浸润程度。Kaplan-Meier 分析和 Cox 回归用于分析 PVT1 与生存率之间的相关性。PVT1 高表达的 BLCA 患者的 10 年疾病特异性生存率（DSS，P < 0.05）和总生存率（OS，P < 0.05）均较低。多因素 Cox 回归分析表明，PVT1（高 vs. 低）（P = 0.004）是独立的预后因素。使用列线图预测 PVT1 对预后的影响。PVT1 在 BLCA 的进展和预后中发挥重要作用，可作为一种中等生物标志物，用于预测膀胱切除术的生存情况。
