Pedersen B K, Abom B
Clin Exp Rheumatol. 1986 Jul-Sep;4(3):249-53.
Pharmacological concentrations of auranofin (oral gold) modulated NK cell activity in a dose dependent biphasic manner. In vitro low doses enhanced NK cell activity, while high doses inhibited the NK cell activity. Sodium aurothiomalate (parenteral gold) had no effect. The effect of auranofin on NK cell function was irreversible and independent of the presence of monocytes. Neither IF nor Il-2 abolished the auranofin-suppressed NK cell activity. When NK cell activity was enhanced by low doses of auranofin, both IF and Il-2 could further boost the NK cell function. Using percoll fractionated NK cell enriched populations in a single cell agarose assays, it was shown that auranofin did not influence effector/target cell conjugate formation. The effect of auranofin on NK cell activity is thus due to an influence on the lytic step.
金诺芬（口服金制剂）的药理浓度以剂量依赖性双相方式调节自然杀伤（NK）细胞活性。在体外，低剂量增强NK细胞活性，而高剂量则抑制NK细胞活性。硫代苹果酸金钠（胃肠外金制剂）无此作用。金诺芬对NK细胞功能的影响是不可逆的，且与单核细胞的存在无关。干扰素（IF）和白细胞介素-2（Il-2）均不能消除金诺芬抑制的NK细胞活性。当低剂量金诺芬增强NK细胞活性时，IF和Il-2均可进一步增强NK细胞功能。在单细胞琼脂糖试验中使用经 Percoll 分级分离的富含NK细胞的群体，结果表明金诺芬不影响效应细胞/靶细胞结合物的形成。因此，金诺芬对NK细胞活性的影响是由于对裂解步骤的影响。
