Abom B, Pedersen B K
Clin Exp Rheumatol. 1987 Jan-Mar;5(1):47-52.
Natural Killer (NK) cell activity was measured in 80 patients with rheumatoid arthritis (RA) grouped according to medication into 1) controls not in remission-inducing therapy, 2) patients treated with oral gold (auranofin), 3) parenteral gold (sodium aurothiomalate) and 4) azathioprine. Baseline, interferon (IF)-enhanced and interleukin 2 (Il-2)-enhanced NK cell activity of patients in the two gold groups did not differ from that of controls, while NK cell activity before and after exposure to IF and Il-2 was significantly suppressed in patients on azathioprine (p less than 0.01). The percentage of Large Granular Lymphocytes did not differ in the four groups while the percentage of Leu 11 positive cells and the total number of lymphocytes were significantly lower in the azathioprine group. Sixty out of 80 patients received nonsteroidal anti-inflammatory drugs (NSAID), whereas 20 did not. A comparison of these two groups showed no influence of NSAID on NK cell activity.
对80例类风湿性关节炎（RA）患者的自然杀伤（NK）细胞活性进行了检测，这些患者根据用药情况分为1）未接受缓解诱导治疗的对照组，2）口服金制剂（金诺芬）治疗的患者，3）胃肠外金制剂（硫代苹果酸金钠）治疗的患者和4）硫唑嘌呤治疗的患者。两个金制剂治疗组患者的基线、干扰素（IF）增强和白细胞介素2（IL-2）增强的NK细胞活性与对照组无差异，而硫唑嘌呤治疗患者在暴露于IF和IL-2前后的NK细胞活性显著受到抑制（p<0.01）。四组患者的大颗粒淋巴细胞百分比无差异，而硫唑嘌呤组中Leu 11阳性细胞百分比和淋巴细胞总数显著更低。80例患者中有60例接受了非甾体抗炎药（NSAID）治疗，而20例未接受。这两组的比较显示NSAID对NK细胞活性无影响。
