合成七酰基脂多糖A的生物学活性，其代表明尼苏达沙门氏菌R595脂多糖A的一个组分。
Biological activity of synthetic heptaacyl lipid A representing a component of Salmonella minnesota R595 lipid A.
作者信息
Galanos C, Lüderitz O, Freudenberg M, Brade L, Schade U, Rietschel E T, Kusumoto S, Shiba T
出版信息
Eur J Biochem. 1986 Oct 1;160(1):55-9. doi: 10.1111/j.1432-1033.1986.tb09939.x.
A synthetic lipid A (preparation 516), containing seven acyl groups and representing one component of natural free lipid A of Salmonella minnesota R595, has been investigated for biological activity in a number of endotoxin test systems. It was found that the synthetic preparation was, in typical in vivo endotoxin tests (lethality, pyrogenicity, Shwartzman reactivity) as well as in its antigenicity and macrophage activation capacity, significantly less active than natural Salmonella lipid A. However, in other in vitro assay systems (B-cell mitogenicity, complement activation, Limulus amoebocyte lysate gelation) it expressed similar activity as Salmonella lipid A.
一种合成脂多糖A（制剂516），含有七个酰基，代表明尼苏达沙门氏菌R595天然游离脂多糖A的一个组分，已在多个内毒素测试系统中研究其生物活性。结果发现，该合成制剂在典型的体内内毒素测试（致死性、致热性、施瓦茨曼反应性）以及抗原性和巨噬细胞激活能力方面，活性明显低于天然沙门氏菌脂多糖A。然而，在其他体外测定系统（B细胞促有丝分裂性、补体激活、鲎变形细胞溶解物凝胶化）中，它表现出与沙门氏菌脂多糖A相似的活性。
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